91996-54-2
91996-54-2 structure
- Name: Trichlormethiazide sodium
- Chemical Name: Trichlormethiazide sodium
- CAS Number: 91996-54-2
- Molecular Formula: C8H8Cl3N3NaO4S2
- Molecular Weight: 403.65
- Catalog: Research Areas Metabolic Disease
- Create Date: 2022-08-17 19:49:52
- Modify Date: 2023-04-15 12:42:57
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Trichlormethiazide sodium is an orally active thiazide diuretic, with antihypertensive effect. Trichlormethiazide sodium increases urine volume (UV), Na and K excretion and tends to improve the depressed creatinine clearance (CCRE) in acute renal failure rats model[1][2].
| Name | Trichlormethiazide sodium |
|---|
| Description | Trichlormethiazide sodium is an orally active thiazide diuretic, with antihypertensive effect. Trichlormethiazide sodium increases urine volume (UV), Na and K excretion and tends to improve the depressed creatinine clearance (CCRE) in acute renal failure rats model[1][2]. |
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| Related Catalog | |
| In Vivo | Trichlormethiazide (1 mg/kg; p.o.; once) sodium increases urinary volume, sodium and potassium excretion in rats[1]. Trichlormethiazide (10 mg/kg, i.v.; daily for 5 days) sodium significantly reduces mean arterial pressure (MAP) within 24 h in high salt intake (HS) rats receiving angiotensin II, but does not affect MAP in any other group[2]. Animal Model: Male Wistar rats, weighing 170-300 g[1] Dosage: 1 mg/kg Administration: Oral administration, once Result: Significantly increased potassium excretion in normal rats. Significantly increased urinary volume, sodium and potassium excretion in cisplatin-induced ARF (acute renal failures) rats. Animal Model: Male Sprague-Dawley rats (350-450 g)[2] Dosage: 10 mg/kg Administration: Intravenous injection, daily, for 15 days Result: Produced a significant fall in MAP in rats on combined angiotensin II and high salt intake. |
| References |
| Molecular Formula | C8H8Cl3N3NaO4S2 |
|---|---|
| Molecular Weight | 403.65 |