8,11,14-Eicosatriynoic Acid, as an inhibitor of prostaglandins, leukotriene biosynthesis and arachidonic acid-induced platelet aggregation, blocks human 12-lipoxygenase (12-LO), cyclooxygenation The enzyme (COX) and 5-lipoxygenase (5-LO) IC50 values were 0.46 μM, 14 μM and 25 μM, respectively. In addition, it inhibits the action of slow-reacting substances of allergic reactions with IC50 values of 10 μM [1,2]. Lipoxygenase is widely found in fungi, plants and animals, and its content is very high. 12-LO is involved in many important disease states and may play a role in oxidative glutamate toxicity. COX enzymes play complex roles in human physiology and pathology involving the neuronal, immune, renal, cardiovascular, gastrointestinal and reproductive systems. COX enzymes are blocked by aspirin and various other NSAIDs, making them clinically important [3]. 5-LO is involved in cancer pathology. It is expressed by a variety of cancer cells, including colon, lung, breast, and prostate cancers, and promotes cancer cell growth and neovascularization. In vitro: As of now, in vitro studies of 8,11,14-eicosatriynoic acid are still under development. In vivo: To date, in vivo studies of 8,11,14-eicosatriynoic acid are in the development stage. References: [1]. Goetz, J., Sprecher, H., Cornwell, D. and Panganamala, R . Inhibition of prostaglandin biosynthesis by triynoic acid. . prostaglandins. 1976;12(2):187-192. [2]. Sun, F., McGuire, J., Morton, D., Pike, J., Sprecher, H. and Kunau, W. Inhibition of platelet arachidonic acid 12-lipoxygenase by acetylenic acid compounds effect. prostaglandins. 1981;21(2):333-343. [3]. Fitzpatrick, F. Cyclooxygenase: regulation and function. Current Drug Design. 2004;10(6):577-588.
4-Azido-L-phenylalanine hydrochloride is an unnatural amino acid, which is used as an effective vibrational reporter of local protein environments.
Ethyl pivaloylacetate is a β-ketoester. Ethyl pivaloylacetate can be uesd as the substrate to evaluate the activity and stereoselectivity of the ketoreductase tool-box[1].
2'',4''-Di-O-(E-p-Coumaroyl)afzelin (compound 36) is a compound isolated from Epimedium sagittatum[1].
23-Nor-6-oxopristimerol is a phenolic dinor-triterpene[1].
Propafenone D7 hydrochloride is the deuterium labeled Propafenone, which is a classic anti-arrhythmic medication.
TRPA1 Antagonist 3 is a photoswitchable TRPA1 agonist that enables optical control of the TRPA1 channel.
hRIO2 kinase ligand-1 (com 9) is a ligand of hRIO2 kinase, with a Kd value of 520 nM[1].
Boc-Leu-Lys-Arg-AMC is a fluorogenic substrate for the Kex2 endoprotease[1].
2-Nitrobenzoic acid-d4 is the deuterium labeled 2-Nitrobenzoic acid[1].
1-(2-Hydrazinyl-2-oxoethyl)pyridin-1-ium-d5 (bromide) is deuterium labeled 1-(2-Hydrazinyl-2-oxoethyl)pyridin-1-ium (bromide).
4-(2-Carboxyphenyl)-7-diethylamino-2-(7-diethylamino-2-oxochroman-3-yl)-chromylium perchlorate is a carboxyl functionalized organic fluorescent dye (λex~650 nm, λem~690 nm)[1].
4-Nitrophenyl Laurate is a class of 4-nitrophenyl ester, which can be used as enzyme substrate[1].
trans-4-Nitrocinnamoyl chloride is used as derivatization reagent[1].
20,26-Dihydroxyecdysone is a predominant ecdysteroid metabolite[1].
N4-Methylcytidine (Nsc518744) is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].
[C3MPr]NTf2 is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
G4RGDSP, Integrin-binding peptide is a cell integrin-binding peptide that targets integrin receptors. G4RGDSP, integrin-binding peptide is coupled to alginate to increase the viability of cells in the scaffold. G4RGDSP, integrin-binding peptide can be used as an extrudable carrier for chondrocyte delivery for the study of 3D printing technology[1][2]
5'-O-DMT-PAC-dA can be used in the synthesis of oligoribonucleotides[1].
m7GpppGmpG, an oligonucleotide, is an M7GpppNpG trinucleotide cap analogue. m7GpppGmpG can be used as a chemical tool enabling manufacturing of RNA featuring either cap 0 or cap 1 structures[1].
5-Methyl-2'-O,4'-C-methylenecytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].
Halo-DBCO is a click chemistry reagent containing dibenzocyclooctyne (DBCO). Halo-DBCO can be used as a ligand to react with HaloTag to form covalent HaloTag ligand couples.
Arachidonoyl Thio-PC is a substrate of many phospholipase A2 (PLA2), including sPLA2, cPLA2 and iPLA2. Cleavage of sn-2 fatty acids by PLA2 results in the production of free thiols, which react with chromogenic reagents such as DTNB (Ellman's reagent) and DTP, allowing quantification of PLA2 activity. Isozyme-specific cPLA2 activity can be measured by depleting or inhibiting sPLA2 and iPLA2 activity in the assay.
Ethyl-L-NIO hydrochloride is a potent and competitive human dimethylarginine dimethylaminohydrolase 1 (hDDAH-1) inhibitor with an IC50 of 70 μM and a Ki of 32 μM[1].
Oleanolic acid-3-O-glucosyl(1-2)xylyl(1-3)glucosiduronic acid is a nature occurring triterpene saponin[1].
Cy3 NHS (Cyanine3 NHS ester) is a water-soluble and yellow emitting fluorescent dye for labeling amino-groups in biomolecules. Used to label soluble proteins, peptides, and oligonucleotides/DNA.
FITC is a derivative of fluorescein for the labeling of amines.
Methylthiomcresol-C5-COOH (Compound F4) is a hapten that can be conjugated to carrier proteins for antigen design. Methylthiomcresol-C5-COOH designed antigen can be applied in ELISA to detect the residual amount of fenthion in white wine samples[1].
MA-2029 is a selective, orally active, and competitive motilin receptor antagonist (IC50=4.9 nM). MA-2029 is selective for the motilin receptor over various other receptors and ion channels. MA-2029 may be useful for gastrointestinal disorders associated with disturbed gastrointestinal motility[1].
Ethyl2-hydroxy-4-methylpentanoate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.