Pipendoxifene is a selective estrogen receptor modulator (SERM).
4-Methoxybenzylamine-d3 is the deuterium labeled Fmoc-Ser(tBu)-OH[1].
A031 is a highly effective PROTAC androgen receptor (AR) degrader with an IC50 value less than 0.25 μM for AR protein degradation. A031 has an inhibitory effect on tumor growth in zebrafish with human prostate cancer (VCaP)[1].
Sulesomab (IMMU-MN3) is a murine monoclonal antibody fragment of the IgG1 class that binds to Normal Cross-Reactive Antigen-90 present on leukocytes. Sulesomab is cleared into infection nonspecifically through increased capillary membrane permeability[1].
Isodonal is a N-pentane diterpene compound with potential cytotoxic, antitumor, inhibitory oxidative phosphorylation and antiingestion activities. Isodonal can be isolated from the leaves of Isodon wikstroemioides and is used in the study of gastrointestinal diseases, anti-tumor and anti-inflammatory[1].
Transketolase-IN-3 is a potent transketolase (TK) inhibitor. Transketolase-IN-3 has herbicidal activity and has inhibitory effects against Digitaria sanguinalis (DS) and Amaranthus retroflexus (AR). Transketolase-IN-3 can be used for the research of herbicides[1].
AP1867 is a synthetic FKBP12F36V-directed ligand.
Rutarensin is a phenolic compound found in Ruta chalepensis cell culture[1].
H-Glu(OcHex)-OH is a glutamic acid derivative[1].
Ganglioside GD3 disodium salt is a melanoma-associated antigen and has been used as a target for the immune therapy of melanomas[1].
CMI-392 is a dual 5-lipoxygenese inhibitor and platelet-activating factor (PAF) receptor antagonist with IC50s of 100 and 10 nM, respectively.
DHX9-IN-6 (Compound 621) is an ATP-dependent inhibitor of RNA helicase A (DHX9) with potential for cancer research[1].
Furostan, β-D-glucopyranoside deriv (compound 2) is a oligofurostanoside that can be found in Asparagus cochinchinensis.
TXNIP-IN-1 is TXNIP-TRX (thioredoxin-interacting protein- thioredoxin) complex inhibitor extracted from patent US20200085800A1, Compound 1. TXNIP-IN-1 can be used in the research of TXNIP-TRX complex associated metabolic disorder (diabetes), cardiovascular disease, or inflammatory disease[1].
DL-Propargylglycine is a Glycine (HY-Y0966) derivative[1].
MBC-11 is a first-in-class conjugate of the bone-targeting bisphosphonate etidronate covalently linked to the antimetabolite cytarabine (araC). Has potential to treat tumor-induced bone disease (TIBD)[1].
Solamargine is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicinal herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cells. IC50 value:Target: Anticancer natural compoundin vitro: Solamargine reduced HepG2 cell viability in a concentration-dependent manner. At 7.5μM solamargine decreased cell viability by less than 20% in HepG2 cells. At the highest dose, solamargine decreased cell migration and invasion by more than 70% and 72% in HepG2 cells, respectively. Western blotting and gelatin zymography results showed that solamargine reduced expression and function of MMP-2 and MMP-9 proteins [1]. SM increased phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK) in a time-dependent fashion. SM also inhibited phosphorylation and protein expression of signal transducer and activator of transcription 3 (Stat3), a transcription factor, which was abrogated by the SB203580, a specific inhibitor of p38 MAPK. In addition, SM induced protein expression of p21, one of cyclin-dependent kinase inhibitors, and this was not observed in cell overexpression of Stat3 or cells treated with SB203580 [2]. SM significantly inhibited the growth of SMMC-7721 and HepG2 cells and induced cell apoptosis. Cell cycle analysis revealed that SM caused cell cycle arrest at the G2/M phase. Moreover, SM could up-regulate the expression of caspase-3 [3].
Jatrophane 4 is a secondary metabolite of Euphorbia peplus. Jatrophane 4 is a diterpene[1].
BLT-1, a thiosemicarbazone copper chelator, is a selectively scavenger receptor B, type 1 (SR-BI) inhibitor. BLT-1 inhibits the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by SR-BI. BLT-1 has pro-inflammatory functions through neutrophil recruitment[1][2][3].
D-Heptamannuronic acid, an alginate oligomer, is produced by marine brown algae and by a limited range of Gram negative bacteria. D-Heptamannuronic acid can be used for the research of pain and vascular dementia[1][2][3][4].
AZD9496 is a potent and selective estrogen receptor (ERα) antagonist with an IC50 of 0.28 nM.
DHAPC is a phospholipid that is very sensitive to oxidation[1].
BV02 is a potent 4-3-3 PPI (14-3-3 protein–protein interaction) inhibitor. BV02 shows cytotoxicity for hematopoietic cells expressing the IM (imatinib mesylate)-sensitive wild type Bcr-Abl and the IM-resistant T315I mutation. BV02 has the potential for the research of chronic myeloid leukemia[1][2].
Protoapigenin is a flavonoid, that can be isolated from the aerial parts of Macrothelypteris torresiana[1].
Dibutepinephrine is a sympathomimetic molecular[1].
Pseudoaspidin is isolated from the ferns of the class Pterophyta or Filicinae[1].
Fmoc-Asn(Dmcp)-OH is an asparagine derivative[1].
Heptaminol hydrochloride is a vasoconstrictor, used in the treatment of low blood pressure, particularly orthostatic hypotension.in vivo: In the rat, Heptaminol hydrochloride prevents orthostatic hypotension, and increases the noradrenaline plasma concentration. In bovine chromaffin cells maintained in primary cultures, Heptaminol hydrochloride is found to be a competitive inhibitor of noradrenaline uptake.[1]
Fmoc-NH-PEG6-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG6-alcohol is extracted from patent WO2016030791, example comp 91[1].
Polyoxyl 40 stearate can be used as an excipient. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1].