N-(4-Methoxy-1,3-benzothiazol-2-yl)-N-methylglycine is a Glycine (HY-Y0966) derivative[1].
Pterosin D is a sesquiterpenoid, that can be isolated from aerial plants of P. cretica[1].
H-L-Ser(Propargyl)-OH hydrochloride is a click chemistry reagent containing an alkyne group[1].
Gangliotetraose (Gg4) is a tetrasccharide, exhibits major components including GM1 and its sialylated derivatives. GM1 facilitates efflux of nuclear Ca2+ and reduces the level of nuclear Ca2+ that characterizes the differentiated neuron. GM1 affects neuronal plasticity and repair mechanisms, as well as neurotrophin release in the brain[1][2].
Trometamol(Tris),for molecular biology-d11 is the deuterium labeled Trometamol(Tris),for molecular biology[1].
Interphotoreceptor Retinoid Binding Protein Fragment (IRBP), a 20-residue peptide and a major pathogenic epitope, is present in the first homologous repeat of the interphotoreceptor retinoid binding protein peptide (IRBP 161–180), which can induce posterior uveitis (EAU)[1].
BG dimer is a molecular dimer organic luminogen with aggregation-induced emission.
APTAB is a fluorescent cationic membrane probe. APTAB locates the anthracene-labeled molecules incorporated into model membranes by fluorescence quenching[1].
L-Proline 4-methoxy-β-naphthylamide hydrochloride (H-Pro-4MβNA hydrochloride) can be used for Fap-activated anti-tumor compounds preparaction[1].
Celloheptaose is an oligosaccharide, consisting of seven glucose residues. Celloheptaose is the substrate of Polysaccharide monooxygenases (PMOs), to generate oxidized cellulo-oligosaccharides[1][2].
3-O-Acetyl-20-Hydroxyecdysone is an steroid isolated from the roots of Cyanotis arachnoidea C.B.Clark.
Lucatumumab (HCD122) is a fully human anti-CD40 antagonist monoclonal antibody, which blocks CD40/CD40L-mediated signaling. Lucatumumab efficiently mediates antibody-dependent cell-mediated cytotoxicity (ADCC) and clearance of tumor cells, can be used for refractory lymphomas, CLL and multiple myeloma research[1][2].
3-Chloropyridine-d4 is the deuterium labeled 3-Chloropyridine[1].
CGP 65015 is an oral iron chelator, which can mobilize iron deposits.
Anthragallol can insert base pairs of DNA. Anthragallol exhibits cytotoxicity by binding to DNA[1].
Ro 48-8071 fumarate is an inhibitor of OSC (Oxidosqualene cyclase) with IC50 of appr 6.5 nM.
14:0-16:1-14:0 TG-d5 is deuterium labeled 14:0-16:1-14:0 TG.
CIzyme Collagenase MA is comprised of highly purified collagenase isoforms I and II from Clostridium histoliticum. CIzyme Collagenase MA can be used for digestion of the pancreas[1].
N-Fmoc-L-valine N-succinimidyl ester is a valine derivative[1].
6-Epiphysalin G is isolated from naturalPhysalis alkekengi var. francheti.[1].
PonatiLink-1-24 is an Abelson murine leukemia (ABL) enzyme inhibitor[1].
H-Phe-OtBu.HCl is a phenylalanine derivative[1].
Pimecrolimus is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12.Target: OthersPimecrolimus blocks T-lymphocyte activation pathway by inhibiting calcineurin function [1]. Pimecrolimus prevents the release of cytokines and pro-inflammatory mediators from mast cells. Pimecrolimus binds to macrophilin-12, the pimecrolimusmacrophilin complex then binds to the cytosolic enzyme calcineurin phosphatase. The pimecrolimus-macrophilin complex prevents the dephosphorylation of the cytoplasmic component of the nuclear factor of activated T cells by inhibiting the action of calcineurin. Pimecrolimus inhibits not only the transcription and synthesis of cytokines from mast cells, but also the release of preformed mediators serotonin and β-hexosaminidase by the inhibition of Fcε-RI-mediated degranulation and secretion. Pimecrolimus treatment causes a strong down-regulation of the expression of mRNA for genes associated with the macrolactam target pathway and inflammation [2].Pimecrolimus is found to be as effective as cyclosporine A following oral ingestion and slightly superior after subcutaneous administration in mice. Pimecrolimus contrasts cyclosporine A and tacrolimus by inhibiting ongoing secondary inflammatory response, but not impairing the primary immune response in allergic contact dermatitis in mice. [2] Pimecrolimus is as effective as the high-potency corticosteroid clobetasol-17-propionate in a pig model of allergic contact dermatitis (ACD). Pimecrolimus also effectively reduces skin inflammation and pruritus in hypomagnesemic hairless rats, a model that mimics acute signs of atopic dermatitis [3].
DL-Tartaric acid is a non-racemic mixture of L- and D-tartaric acids with antioxidant activities[1][2].
Dithranol is highly effective in the treatment of psoriasis.Target: OthersDithranol accumulates in mitochondria where it interferes with the supply of energy to the cell, probably by the oxidation of dithranol releasing free radicals. This impedes DNA replication and so slows the excessive cell division that occurs in psoriatic plaques. In addition Dithranol may act by reducing the elevated levels of cGMP that occurs in psoriasis.
Patent Blue V has been widely used in sentinel lymph node mapping. Patent Blue V is also a food coloring agent and an alternative dye for trypan blue (TB) in descemet membrane endothelial keratoplasty (DMEK)[1].
LHRH (1-5) (free acid) is a polypeptide generated by the cleavage of LHRH at the Tyr55-Gly66 site. LHRH (1-5) (free acid) is converted into LHRH (1-3) and LHRH (4-5) fragments under the catalysis of Angiotensin-converting enzyme (HY-P2983)[1][2].
rel-Boc-Hyp-OMe is the inactive isomer of Boc-Hyp-OMe (HY-65039), and can be used as an experimental control. Boc-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].
9-O-Acetyl-fargesol is a lignan, which can be isolated from the seeds of Magnolia praecocissima[1].
Pseudopelletierine is an alkaloid compound that can be used as a enzyme substrate[1].