Dithranol

Modify Date: 2024-01-02 12:02:39

Dithranol structure	Common Name	Dithranol
	CAS Number	1143-38-0	Molecular Weight	226.227
	Density	1.4±0.1 g/cm3	Boiling Point	464.1±45.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₁₀O₃	Melting Point	178-181 °C(lit.)
	MSDS	Chinese USA	Flash Point	248.6±25.2 °C
	Symbol	GHS07	Signal Word	Warning

Use of Dithranol

Dithranol is highly effective in the treatment of psoriasis.Target: OthersDithranol accumulates in mitochondria where it interferes with the supply of energy to the cell, probably by the oxidation of dithranol releasing free radicals. This impedes DNA replication and so slows the excessive cell division that occurs in psoriatic plaques. In addition Dithranol may act by reducing the elevated levels of cGMP that occurs in psoriasis.

Name	anthralin
Synonym	More Synonyms

Description	Dithranol is highly effective in the treatment of psoriasis.Target: OthersDithranol accumulates in mitochondria where it interferes with the supply of energy to the cell, probably by the oxidation of dithranol releasing free radicals. This impedes DNA replication and so slows the excessive cell division that occurs in psoriatic plaques. In addition Dithranol may act by reducing the elevated levels of cGMP that occurs in psoriasis.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. http://en.wikipedia.org/wiki/Dithranol

Density	1.4±0.1 g/cm3
Boiling Point	464.1±45.0 °C at 760 mmHg
Melting Point	178-181 °C(lit.)
Molecular Formula	C₁₄H₁₀O₃
Molecular Weight	226.227
Flash Point	248.6±25.2 °C
Exact Mass	226.062988
PSA	57.53000
LogP	4.16
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.710
Storage condition	2-8°C
Stability	Stable. Combustible. Incompatible with strong oxidizing agents.

Dithranol MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CB8927000

CHEMICAL NAME :: Anthrone, 1,8-dihydroxy-

CAS REGISTRY NUMBER :: 1143-38-0

BEILSTEIN REFERENCE NO. :: 2054360

LAST UPDATED :: 199706

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C14-H10-O3

MOLECULAR WEIGHT :: 226.24

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	CB8927000
HS Code	2914400090

Precursor 8
CAS#:117-10-2 Dantron CAS#:641-70-3 3-Nitrophthalic... CAS#:89646-23-1 2-(2-hydroxyben... CAS#:69595-66-0 1,8-bis(benzylo...
CAS#:3360-93-8 10-acetyl-1,8,9... CAS#:81-64-1 Quinizarin CAS#:89646-24-2 3-amino-2-(2-hy... CAS#:89646-25-3 3-hydroxy-2-(2-...
DownStream 10
CAS#:104608-82-4 10-ethyldithranol CAS#:1963-82-2 9,10-Anthracene... CAS#:2891-30-7 9(10H)-Anthrace... CAS#:3022-61-5 10-acetyl dithranol
CAS#:117-10-2 Dantron CAS#:31991-54-5 1,8,1',8'-tetra... CAS#:64817-79-4 1,8,10-trihydro... CAS#:122993-74-2 7-(4,5-dihydrox...
CAS#:122993-75-3 6-(9,10-dihydro... CAS#:64817-77-2 (9-oxo-8-tetrad...

HS Code	2914400090
Summary	2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

Reactive matrices for matrix-assisted laser desorption/ionization mass spectrometry of primary amines.

Eur. J. Mass Spectrom. (Chichester, Eng.) 21 , 403-11, (2015)

Some aromatic carbonyl compounds [2,4-dihydroxybenzaldehyde (2,4-DHBA), 2,5- dihydroxyacetophenone (DHAP), 2,3,5-trihydroxybenzaldehyde and 2,4-dinitrobenzaldehyde] were examined as potential reactive...

Optimization of matrix assisted desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS) for the characterization of Bacillus and Brevibacillus species.

Anal. Chim. Acta 840 , 49-57, (2014)

Over the past few decades there has been an increased interest in using various analytical techniques for detecting and identifying microorganisms. More recently there has been an explosion in the app...

1,8,9-Trihydroxyanthracene

Anthralin

Dithranol

Cigthranol

MFCD00053409

UNII-U8CJK0JH5M

Batridol

1,8-Dihydroxy-9(10H)-anthracenone

1,8,9-Anthracenetriol (1,8-Dihydroxy-9(10H)-anthracenone

1,8-dihydroxy-9-anthrone

1,8-Dihydroxyanthracen-9(10H)-one

EINECS 214-538-0

9(10H)-Anthracenone, 1,8-dihydroxy-

MFCD00001250

1,8-dihydroxy-10H-anthracen-9-one

1,8-dihydro-9,10H-anthracenone

Chrysodermol

Anthrone,1,8-dihydroxy

1,8-Dihydroxyanthrone

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Dithranol
Price: ￥255.0/1g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Anthralin
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: Dithranol
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFU CHEM---ANTHRALIN
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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