Dithranol

Names

[ Name ]:
Dithranol

[Synonym ]:
1,8,9-Trihydroxyanthracene
Anthralin
Dithranol
Cigthranol
MFCD00053409
UNII-U8CJK0JH5M
Batridol
1,8-Dihydroxy-9(10H)-anthracenone
1,8,9-Anthracenetriol (1,8-Dihydroxy-9(10H)-anthracenone
1,8-dihydroxy-9-anthrone
1,8-Dihydroxyanthracen-9(10H)-one
EINECS 214-538-0
9(10H)-Anthracenone, 1,8-dihydroxy-
MFCD00001250
1,8-dihydroxy-10H-anthracen-9-one
1,8-dihydro-9,10H-anthracenone
Chrysodermol
Anthrone,1,8-dihydroxy
1,8-Dihydroxyanthrone

Biological Activity

[Description]:

Dithranol is highly effective in the treatment of psoriasis.Target: OthersDithranol accumulates in mitochondria where it interferes with the supply of energy to the cell, probably by the oxidation of dithranol releasing free radicals. This impedes DNA replication and so slows the excessive cell division that occurs in psoriatic plaques. In addition Dithranol may act by reducing the elevated levels of cGMP that occurs in psoriasis.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. http://en.wikipedia.org/wiki/Dithranol

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
464.1±45.0 °C at 760 mmHg

[ Melting Point ]:
178-181 °C(lit.)

[ Molecular Formula ]:
C₁₄H₁₀O₃

[ Molecular Weight ]:
226.227

[ Flash Point ]:
248.6±25.2 °C

[ Exact Mass ]:
226.062988

[ PSA ]:
57.53000

[ LogP ]:
4.16

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.710

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CB8927000

CHEMICAL NAME :: Anthrone, 1,8-dihydroxy-

CAS REGISTRY NUMBER :: 1143-38-0

BEILSTEIN REFERENCE NO. :: 2054360

LAST UPDATED :: 199706

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C14-H10-O3

MOLECULAR WEIGHT :: 226.24

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
CB8927000

[ HS Code ]:
2914400090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914400090

[ Summary ]:
2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

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