trans-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate

Modify Date: 2024-04-03 10:51:26

trans-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate Structure
trans-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate structure
Common Name trans-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate
CAS Number 1145663-09-7 Molecular Weight 245.27
Density N/A Boiling Point N/A
Molecular Formula C11H19NO5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of trans-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate


rel-Boc-Hyp-OMe is the inactive isomer of Boc-Hyp-OMe (HY-65039), and can be used as an experimental control. Boc-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].

 Names

Name rel-Boc-Hyp-OMe

  Biological Activity

Description rel-Boc-Hyp-OMe is the inactive isomer of Boc-Hyp-OMe (HY-65039), and can be used as an experimental control. Boc-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].
Related Catalog
References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.  

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.  

 Chemical & Physical Properties

Molecular Formula C11H19NO5
Molecular Weight 245.27
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