Atilotrelvir is antiviral agent, can inhibit coronavirus, picornavirus and norovirus infection[1].
Pramiracetam is a nootropic drug derived from piracetam, and is more potent. Pramiracetam reportedly improved cognitive deficits associated with traumatic brain injuries. IC50 Value: Target: in vitro: Pramiracetam sulfate did not exhibit any affinity in vitro for dopaminergic , GABAergic, serotoninergic, adrenergic, muscarinic, adenosine (IC50 > 10 uM), and benzodiazepine receptors (IC50 > 1 uM) binding sites [1].in vivo: In a double-blind, randomized design, two groups of six subjects each received alternating placebo and single 400, 800, 1,200, and 1,600 mg oral doses of pramiracetam after an overnight fast. Mean (+/- SD) peak plasma concentrations of the four dose groups (2.71 +/- 0.54, 5.40 +/- 1.34, 6.13 +/- 0.71, 8.98 +/- 0.71 micrograms/mL) were attained between two to three hours following drug administration [2]. Two doses of pramiracetam (7.5 mg/kg and 15 mg/kg) were administered daily prior to testing for 7 weeks in a 16-arm radial maze in which nine arms were baited with food [3].
Etosalamide is an antipyretic and analgesics, used as an anti-inflammatory drug.
Gamitrinib TPP hexafluorophosphate is a Gamitrinib (GA) mitochondrial matrix inhibitor.
1-(3-(1-Hydroxy-3-methylbutyl)-4-methoxyphenyl)ethan-1-one is a 1,2,5-trisubstituted methoxyacetophenone derivative that isolated from Mikania minima[1].
Direct Grey D exhibits frameshift mutagenic activity[1].
(tert-Butoxycarbonyl)-L-methionine is a Methionine (HY-13694) derivative[1].
β-Phellandrene is obtained from Canada-balsam oil by fractional distillation. β-Phellandrene can be used to essential oil additives[1].
2,3-Diphospho-D-glyceric acid pentasodium salt is a highly anionic polyphosphorus compound. 2,3-Diphospho-D-glyceric acid is present in the concave center of red blood cells, it binds hemoglobin to reduce its oxygen affinity. 2,3-Diphospho-D-glyceric acid is an endogenous, selective inhibitor of vascular calcification (VC) and significantly delays the formation of crystalline calpain particles (CPP). 2,3-Diphospho-D-glyceric acid also inhibits calcification in mouse vascular smooth muscle cell line (MOVAS) without cytotoxic effects[1].
Oxyphyllacinol, also known as Benzenepentanol, is a natural product found in Alpinia oxyphylla (Yizhi) capsularfruits which are commonly used in traditional medicine. Oxyphyllacinol is an antioxidant.
RLLFT-NH2 is a reversed amino acid sequence negative control peptide for TFLLR-NH2[1].
Lotrafiban is an orally-active platelet GPIIb/IIIa blocker for treatment of coronary and cerebrovascular disease.
Ethephon is a plant growth regulator[1].
(S)-2-(2-(1H-Indol-3-yl)acetamido)-3-phenylpropanoic acid is a phenylalanine derivative[1].
4'-Methyl-β-naphthoflavone is a metabolite of Naphthoflavones (benzoflavones) in fungal. Naphthoflavones are activators or inhibitors of CYP-450[1].
Eglatoprutug is an humanized immunoglobulin G1-kappa, anti-c-Kit monoclonal antibody[1].
Indole-3-butyric acid (3-indolebutyric acid; IBA) is a plant growth auxin and a good rooting agent. It can promote herbs and woody ornamental plant rooting and used for improving fruit rate.
NMT-IN-1 (compound 9) is a potent N-Myristoyltransferase (NMT) Inhibitor with IC50 values of 31 and 66 μM for TbNMT and hNMT, respectively. NMT-IN-1 can be used in research of african trypanosomiasis[1].
N4-Benzoyl-7’-O-(4,4’-dimethoxytrityl oxy)morpholinocytosine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].
OSMI-1 is a cell-permeable, small molecule O-GlcNAc transferase (OGT) inhibitor with IC50 of 2.7 uM; inhibits protein O-GlcNAcylation in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans; also significantly decreases HSV replication.
(E)-Benzyl ferulate is a phenolic ester that can be isolated from Thai propolis[1].
5-Sulfosalicylic acid is a sulfonated salicylic acid derivative. 5-Sulfosalicylic acid is effective against the breast cancer cell line, MCF-7, with less toxicity[1]. 5-Sulfosalicylic acid has antioxidant activities[2].
Mouse TREM-1 SCHOOL peptide (Mouse TREM-1(213-221), GF9) targets interactions between TREM-1 and its signaling partner DAP-12, and inhibits TREM-1 signaling. Mouse TREM-1 SCHOOL peptide has antitumor effect[1].
Asiaticoside B is a triterpene glycoside isolated from Actaea asiatica, with anti-cancer activity[1].
H-γ-Glu-Gln-OH is a hydrophilic peptide and can be conjugated to drugs. The carrier composed of H-γ-Glu-Gln-OH has the characteristics of high water solubility and drug-loading capacity, good biocompatibility, low toxicity, improved tumor targeting ability, and anti-tumor efficacy[1].
DDAO-C6 is a cridone ester derivative, highly specific fluorescence for detecting human serum albumin (HSA). DDAO-C6 acts as an enzymatic activatable near-infrared fluorescent probe in visually sensing endogenous lipase from gut microbes (Ex/Em=600/658 nm)[1][2].
Hexapeptide-3isa bioactive peptide with repair skin effect and has been reported used as a cosmetic ingredient[1].
Biotin-PEG4-MeTz is a click chemistry reagent containing a terminal methyltetrazine group that reacts with trans-cyclooctene. Biotin-PEG4-MeTz can be used for the preparation of biotinylated conjugates[1].
trans-AUCB (t-AUCB) is a potent, orally active and selective soluble epoxide hydrolase (sEH) inhibitor with IC50s of 1.3 nM, 8 nM, 8 nM for hsEH, mouse sEH and rat sEH, respectively. trans-AUCB has anti-glioma activity[1][2].
Triptohypol C, a Tripterin (HY-13067) derivative, is a potent Nur77-targeting anti-inflammatory agent with an Kd value of 0.87 μM. Triptohypol C inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1[1].