Lotrafiban

Modify Date: 2025-08-26 03:11:24

Lotrafiban Structure
Lotrafiban structure
Common Name Lotrafiban
CAS Number 171049-14-2 Molecular Weight 428.52500
Density 1.22g/cm3 Boiling Point 730ºC at 760 mmHg
Molecular Formula C23H32N4O4 Melting Point N/A
MSDS N/A Flash Point 395.3ºC

 Use of Lotrafiban


Lotrafiban is an orally-active platelet GPIIb/IIIa blocker for treatment of coronary and cerebrovascular disease.

 Names

Name 2-[(2S)-4-methyl-3-oxo-7-(4-piperidin-4-ylpiperidine-1-carbonyl)-2,5-dihydro-1H-1,4-benzodiazepin-2-yl]acetic acid
Synonym More Synonyms

 Lotrafiban Biological Activity

Description Lotrafiban is an orally-active platelet GPIIb/IIIa blocker for treatment of coronary and cerebrovascular disease.
Related Catalog
References

[1]. Topol EJ, Easton D, Harrington RA, et al. Randomized, double-blind, placebo-controlled, international trial of the oral IIb/IIIa antagonist lotrafiban in coronary and cerebrovascular disease. Circulation. 2003;108(4):399-406.

 Chemical & Physical Properties

Density 1.22g/cm3
Boiling Point 730ºC at 760 mmHg
Molecular Formula C23H32N4O4
Molecular Weight 428.52500
Flash Point 395.3ºC
Exact Mass 428.24200
PSA 101.98000
LogP 2.10820
Vapour Pressure 2.27E-22mmHg at 25°C
Index of Refraction 1.572
InChIKey PYZOVVQJTLOHDG-FQEVSTJZSA-N
SMILES CN1Cc2cc(C(=O)N3CCC(C4CCNCC4)CC3)ccc2NC(CC(=O)O)C1=O

 Synonyms

Lotrafiban
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