Picaridin (Lcaridin) is a topical insect repellent[1].
SF2312, a natural phosphonate Antibiotic (Antibiotic), is a highly potent Enolase (Enolase) inhibitor with IC50s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively. SF2312 is active against bacteria under anaerobic conditions[1].
Leucomycin (kitasamycin) is a macrolide antibiotic produced by Streptomyces kitasatoensis[1][2][3][4].
ALB-109564 (12'-Methylthiovinblastine) hydrochloride, a tubulin inhibitor, is a cytotoxic agent designed to kill cancer cells by disrupting mitosis[1].
PROTAC BRD4-binding moiety 3 is a VHL ligand, which binds to pan-BET inhibitor JQ1 via a linker to form PROTAC[1].
2-(2,6-Dioxopiperidin-3-yl)phthalimidine-C5-Br is a E3 ligase ligand-linker conjugate for PROTAC.
Boc-Cha-OMe is an alanine derivative[1].
(S)-Ro 32-0432 free base is a potent, selective, ATP-competitive and orally active PKC inhibitor. The IC50 values of (S)-Ro 32-0432 free base for PKCα, PKCβI, PKCβII, PKCγ and PKCε are 9.3 nM, 28 nM, 30 nM, 36.5 nM and 108.3 nM, respectively. (S)-Ro 32-0432 free base is also a selective G protein-coupled receptor kinase 5 (GRK5) inhibitor. (S)-Ro 32-0432 free base prevents T-cell activation and has the potential for chronic inflammatory and autoimmune diseases research[1][2].
Nikethamide, one of the respiratory central stimulants, is used to treat respiratory failure in clinical practice.
3-Acetylpinobanksin-7-methyl ether is a natural product that can be isolated from propolis[1].
KRAS G12C inhibitor 55 (Compound 1) is a KRAS G12C inhibitor[1].
CaLL is an antimicrobial peptide. CaLL has antibacterial activity against B. anthracis, B. anthracis (vegetative), and B. cepacia (MIC: 7.8, 31.3, 31.3 μg/mL)[1].
Laurycolactone B is a natural product from Eurycoma longifolia Jack[1].
D-Galactose-13C-4 is the 13C labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose[1][2][3][4].
TAK-659 hydrochloride is a potent, selective and orally available spleen tyrosine kinase (Syk) inhibitor with an IC50 of 3.2 nM.
Fraxidin is a class of coumarin isolated from the roots of Jatropha podagrica, exhibits antibacterial activity against Bacillus subtilis with an inhibition zone of 12 mm at a concentration of 20 µg/disk[1][2].
ML-097 (CID-2160985) is a pan Ras-related GTPases activator that can activate Rac1, cell division cycle 42, Ras, and Rab7[1].
ODN 24987 is a Guanine-modified inhibitory oligonucleotides (ODN), targeting TLR9. ODN 24987 can inhibit IL-6 and IFN-α release. ODN 24987 can be used for research immune disorders. ODN 24987 sequence: 5’-C-C-T-G-G-C-c7G-G-G-G-3’[1].
Pomalidomide-C3-adavosertib is a rapid and selective Wee1 degrader (IC50=3.58 nM). Pomalidomide-C3-adavosertib shows anti-cancer cell proliferation activity, and induces apoptosis[1].
Monomethyl auristatin E intermediate-9 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].
2,3′,4′,5-Tetrachlorobiphenyl-3,4,6-d3 is the deuterium labeled 2,3′,4′,5-Tetrachlorobiphenyl[1].
Cytarabine triphosphate (Ara-CTP), an active metabolite of Cytarabine, is a competitive inhibitor of DNA synthesis. Intracellular Cytarabine triphosphate levels can be used to predict chemosensitivity of leukemic blasts to Cytarabine[1].
AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeant trifluoromethyl ketone analog of arachidonic acid. AACOCF3 is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). AACOCF3 blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. AACOCF3 has the potential for the research of cardiovascular disease[1][2][3].
4-Ethyl-2-methoxyphenol-d5 is the deuterium labeled 4-Ethyl-2-methoxyphenol[1].
Yadanziolide A, a quassinoid glycoside from Brucea javanica, has antitumor activity[1].
IL-17 modulator 5 (compound 26) is a IL-17 inhibitor, with an IC50 of 1 nM[1].
Maysin, a neuroprotective C-glycosyl-flavone, can be isolated from corn silk. Maysinshows protective activity against the damage caused by Syn amyloid aggregates-oligomers and fibrils. Maysinprevents oxidative stress and imbalance of intracellular calcium homeostasis, activating an autophagic degradative process. Maysincan be used for research of Parkinson's disease (PD)[1].
Pseudocoptisine acetate, a quaternary alkaloid with a benzylisoquinoline skeleton, is isolated from the tubers of Corydalis turtschaninovii. Pseudocoptisine acetate shows anti-inflammatory properties[1].
Propylparaben is an antimicrobial agent, preservative, flavouring agent.
14:0-14:0 PC-d27 is deuterium labeled 14:0-14:0 PC.