SF 2312
Modify Date: 2025-08-25 10:01:28
SF 2312 structure
|
Common Name | SF 2312 | ||
|---|---|---|---|---|
| CAS Number | 107729-45-3 | Molecular Weight | 197.08300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C4H8NO6P | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SF 2312SF2312, a natural phosphonate Antibiotic (Antibiotic), is a highly potent Enolase (Enolase) inhibitor with IC50s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively. SF2312 is active against bacteria under anaerobic conditions[1]. |
| Name | (1,5-dihydroxy-2-oxopyrrolidin-3-yl)phosphonic acid |
|---|
| Description | SF2312, a natural phosphonate Antibiotic (Antibiotic), is a highly potent Enolase (Enolase) inhibitor with IC50s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively. SF2312 is active against bacteria under anaerobic conditions[1]. |
|---|---|
| Related Catalog | |
| In Vitro | SF2312 对 ENO1 缺失的神经胶质瘤细胞具有选择性毒性。SF2312 在低 μM 范围内抑制 ENO1 缺失的 D423 神经胶质瘤细胞系的增殖 (处理 2 周)，而同基因 ENO1 拯救的 D423 细胞，异位再表达 ENO1 仅在 SF2312 浓度高于 200 μM 时显示增殖抑制。SF2312 (10 μM) 以剂量依赖性方式减少 U-13C 葡萄糖向 13C 乳酸的转化，其方式对 ENO1 缺失优于 ENO1 拯救或其他 ENO1 -完整的神经胶质瘤细胞[1]。 SF2312 由放线菌小单孢菌产生，对多种细菌均有活性，对沙门氏菌和葡萄球菌活性强，对大肠杆菌活性弱，对真菌无活性[1]。 |
| References |
| Molecular Formula | C4H8NO6P |
|---|---|
| Molecular Weight | 197.08300 |
| Exact Mass | 197.00900 |
| PSA | 128.11000 |
| InChIKey | CGWBGDOPBYWJKZ-UHFFFAOYSA-N |
| SMILES | O=C1C(P(=O)(O)O)CC(O)N1O |