DC Chemicals Limited
China
Product Name: ML075 (SF-11)
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

443292-81-7

443292-81-7 structure

443292-81-7 structure

Name: SF 11
Chemical Name: N-(4-ethoxyphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide
CAS Number: 443292-81-7
Molecular Formula: C₂₇H₃₀N₂O₂S
Molecular Weight: 446.60400
Create Date: 2016-02-28 14:35:04
Modify Date: 2024-01-12 02:17:05
SF 11 is a potent and brain penetrant neuropeptide Y Y2 receptor antagonist (IC50=199 nM). Antidepressant-like activity[1][2].

Name	N-(4-ethoxyphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide
Synonyms	HMS2560N17 N-(4-Ethoxyphenyl)-4-(hydroxydiphenylmethyl)-1-piperidinecarbothioamide SID 17507305

Description	SF 11 is a potent and brain penetrant neuropeptide Y Y2 receptor antagonist (IC50=199 nM). Antidepressant-like activity[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor
Target	NPYY2 receptor:199 nM (IC50)
References	[1]. Domin H, et al. Characterization of the Brain Penetrant Neuropeptide Y Y2 Receptor Antagonist SF-11. ACS Chem Neurosci. 2019;10(8):3454-3463. [2]. Brothers SP, et al. Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening. Mol Pharmacol. 2010;77(1):46-57.

Molecular Formula	C₂₇H₃₀N₂O₂S
Molecular Weight	446.60400
Exact Mass	446.20300
PSA	76.82000
LogP	5.44110

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319
Precautionary Statements	P305 + P351 + P338
RIDADR	NONH for all modes of transport