Volanesorsen is an antisense oligonucleotide targeting Apolipoprotein C-III (APOC3) mRNA to treat patients with the familial chylomicronemia syndrome.
Azetidine-2-carboxylic acid is a non proteinogenic amino acid homologue of proline. Found in common beets. Azetidine-2-carboxylic acid can be misincorporated into proteins in place of proline in many species, including humans. Toxic and teratogenic agent[1][2].
5-Hydroxymebendazole is the one metabolite of Benzimidazoles. Benzimidazoles are safe, broad-spectrum anthelmintic drugs and are widely used for prevention and treatment of parasitic infections in food-producing animals[1].
14-Episinomenine is an alkaloid that can be isolated from Stephania cepharantha[1].
2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid is a tyrosine derivative[1].
1431370-18-1
WAY-359473 is an active molecule.
Safflower red, a red pigment, is isolated from safflower and used as a natural antioxidant in the food, cosmetics and clothing industries.
Isophthalic-2,4,5,6 Acid-d4 is the deuterium labeled Isophthalic acid[1].
17:0-22:4 PI-d5 (ammonium) is deuterium labeled 17:0-22:4 PI (ammonium).
Lacto-N-triose II is a core structural unit of human milk oligosaccharides (HMOs). Lacto-N-triose II owns nutraceutical potentials and can be used in the production of complex HMOs[1].
(4-NH2)-Exatecan, a topoisomerase inhibitor derivative extracted from patent US20200306243A1, compound A. (4-NH2)-Exatecan can be used in the synthesis of antibody-drug conjugates (ADCs)[1].
H-Tyr-OEt.HCl is a tyrosine derivative[1].
Taragarestrant (D-0502) meglumine is a potent, orally active and selective estrogen receptor degrader (SERD). Taragarestrant meglumine shows potent activity in various ER+ breast cancer cell lines and xenograft models[1][2].
Euonymine (Euonymin) is a sesquiterpene pyridine alkaloid isolated from the leaves of Maytenus chiapensis.
KLKKTETQ is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient[1].
Anisylacetone (p-Methoxybenzylacetone) is a male fruit fly attractant[1].
Methylacetylene-d1 is the deuterium labeled Methylacetylene[1].
beta-Glc-TEG-Alkyne is a click chemistry reagent containing an alkynes group. beta-Glc-TEG-Alkyne can be used for the research of various biochemical[1].
Menin-MLL inhibitor 4 is an inhibitor of Menin- MLL (mixed-lineage leukemia protein) interaction extracted from patent WO2017214367, compound example 1. Menin-MLL inhibitor 4 has antitumor activity[1].
Anti-inflammatory agent 37 is a biologically active peptide.
Tiopronin-d3 is the deuterium labeled Tiopronin. Tiopronin is a diffusible antioxidant, an antidote to heavy metal poisoning and a radioprotective agent. Tiopronin can control the rate of cystine precipitation and excretion and has the potential for cystinuria, rheumatoid arthritis and hepatic disorders[1][2].
Mono-Cyclohexyl Phthalate-3,4,5,6-d4 is the deuterium labeled Mono-Cyclohexyl Phthalate[1].
24:1 SM (d18:1/24:1)-d9 is deuterium labeled 24:1 SM (d18:1/24:1).
PPI-2458 is a potent, orally active, selective and irreversible inhibitor of methionine aminopeptidase-2 (MetAP-2). PPI-2458 can be used for arthritis and lymphoma research[1][2].
Phloroglucide is a natural product that can be isolated from ferns[1].
Chrysothol can be isolated from the aerial part of Chrysothamnus viscidiflorus var. and has anticancer activity[1].
CCF642 is a novel PDI-inhibiting compound with antimyeloma activity.The IC50 is 2.9 μmol/L.In vitro: CCF642 inhibit PDI reductase activity about 100-fold more potently than the structurally distinct established inhibitors PACMA 31 and LOC14. CCF642 causes acute ER stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release.In vivo: CCF642 displayed potent efficacy in an aggressive syngeneic mouse model of multiple myeloma and prolonged the lifespan of C57BL/KaLwRij mice engrafted with 5TGM1-luc myeloma, an effect comparable to the first-line multiple myeloma therapeutic bortezomib. CCF642 can be given intravenously without injection reactions in mice with 10 mg/kg.
Sevelamer carbonate is an orally active and non-calcium-based phosphate binding agent and used for the hyperphosphatemia of chronic kidney disease (CKD)research. Sevelamer carbonate effectively lowers serum phosphorus levels hile having minimal effect on serum calcium or serum chloride levels in vivo. Sevelamer carbonate is considered as an improved, buffered form of sevelamer (HY-13995)[1][2].
1-Palmitoyl-2-hydroxy-sn-glycero-3-phosphate-13C16 (sodium) is 13C16 labeled 1-Palmitoyl-2-hydroxy-sn-glycero-3-phosphate.