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60254-95-7

60254-95-7 structure
60254-95-7 structure
  • Name: 5-Hydroxymebendazole
  • Chemical Name: Methyl {6-[hydroxy(phenyl)methyl]-1H-benzimidazol-2-yl}carbamate
  • CAS Number: 60254-95-7
  • Molecular Formula: C16H15N3O3
  • Molecular Weight: 297.30900
  • Catalog: analytical chemistry Standard Analytical standard
  • Create Date: 2017-08-23 06:23:51
  • Modify Date: 2025-08-25 23:51:29
  • 5-Hydroxymebendazole is the one metabolite of Benzimidazoles. Benzimidazoles are safe, broad-spectrum anthelmintic drugs and are widely used for prevention and treatment of parasitic infections in food-producing animals[1].

Name Methyl {6-[hydroxy(phenyl)methyl]-1H-benzimidazol-2-yl}carbamate
Synonyms 5-Hydroxylaminopyridin-2-carbonsaeure
tupichilignan A
5-hydroxymebendazole
5-hydroxymatairesinol dimethyl ether
5-Hydroxylaminopicolinsaeure
Description 5-Hydroxymebendazole is the one metabolite of Benzimidazoles. Benzimidazoles are safe, broad-spectrum anthelmintic drugs and are widely used for prevention and treatment of parasitic infections in food-producing animals[1].
Related Catalog
References

[1]. Hou XL, et al. Development and validation of an ultra high performance liquid chromatography tandem mass spectrometry method for simultaneous determination of sulfonamides, quinolones and benzimidazoles in bovine milk. J Chromatogr B Analyt Technol Biomed Life Sci. 2014;962:20‐29.

Density 1.401g/cm3
Boiling Point 438.82°C (rough estimate)
Molecular Formula C16H15N3O3
Molecular Weight 297.30900
Exact Mass 297.11100
PSA 90.73000
LogP 2.83650
Index of Refraction 1.716

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DD6498000
CHEMICAL NAME :
2-Benzimidazolecarbamic acid, 5-(alpha-hydroxybenzyl)-, methyl ester
CAS REGISTRY NUMBER :
60254-95-7
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C16-H15-N3-O3
MOLECULAR WEIGHT :
297.34
WISWESSER LINE NOTATION :
T56 BM DNJ CMVO1 GYQR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
59200 ug/kg
SEX/DURATION :
female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
59200 ug/kg
SEX/DURATION :
female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Human Cells - not otherwise specified
DOSE/DURATION :
2 mg/L
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 31,505,1976
RIDADR NONH for all modes of transport
RTECS DD6498000
HS Code 2933990090

~87%

60254-95-7 structure

60254-95-7

Literature: Sharma; Ojha; Singh; Bhakuni; Srivastava; Gupta; Katiyar Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1989 , vol. 28, # 8 p. 702 - 704
Precursor  1

DownStream  0

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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