PROTAC Linker

Total: 1884
Updated: 2019-06-28 15:55:20
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.

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PROTAC >
PROTAC E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase PROTAC Linker PROTAC-linker Conjugate for PAC
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BnO-PEG1-CH2COOH

BnO-PEG1-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 93206-09-8
  • MF: C11H14O4
  • MW: 210.22600
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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t-Boc-aminooxy-PEG5-propargyl

Boc-aminooxy-PEG5-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2086688-98-2
  • MF: C18H33NO8
  • MW: 391.46
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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t-Boc-N-amido-PEG6-Tos

t-Boc-N-amido-PEG6-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1264015-76-0
  • MF: C24H41NO10S
  • MW: 535.65
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG1-CH2CO2-t-Bu

Azido-PEG1-C1-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1820717-35-8
  • MF: C8H15N3O3
  • MW: 201.22
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Methylamino-PEG4-acid HCl

Methylamino-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1283658-71-8
  • MF: C12H25NO6
  • MW: 279.330
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 405.5±40.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 199.1±27.3 °C
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1-(3-(Dimethylamino)propyl)-3-ethylurea 1-((3-(2-(2-(((cyclooct-4-en-1-yloxy)carbonyl)amino)ethoxy)ethoxy)propanoyl)oxy)-2,5-dioxopyrrolidine-3-sulfonate

TCO-PEG2-Sulfo-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2353409-48-8
  • MF: C28H49N5O12S
  • MW: 679.78
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Amino-PEG11-acid

Amino-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1415408-69-3
  • MF: C27H55NO14
  • MW: 617.72
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Triethylene glycol monododecyl ether

Triethylene glycol monododecyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 3055-94-5
  • MF: C18H38O4
  • MW: 318.492
  • Catalog: PROTAC Linker
  • Density: 0.9±0.1 g/cm3
  • Boiling Point: 412.0±25.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 202.9±23.2 °C
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Azido-PEG3-succinimidyl carbonate

Azido-PEG3-O-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2110448-98-9
  • MF: C13H20N4O8
  • MW: 360.32
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG8-NHBoc

Azido-PEG8-NHBoc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 2231845-12-6
  • MF: C23H46N4O10
  • MW: 538.63
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Aminooxy-PEG2-alcohol

Aminooxy-PEG2-alcohol is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminooxy-PEG2-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

  • CAS Number: 185022-12-2
  • MF: C4H11NO3
  • MW: 121.14
  • Catalog: ADC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N-(Boc-PEG1)-N-bis(PEG2-propargyl)

N-(Boc-PEG1)-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2100306-63-4
  • MF: C23H40N2O7
  • MW: 456.57
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Biotin-PEG3-C3-NH2

Biotin-PEG3-C3-NH2 is a PEG-based PROTAC linker, with NH2 functional group, that can be used in the synthesis of PROTACs[1].

  • CAS Number: 183896-00-6
  • MF: C20H38N4O5S
  • MW: 446.60
  • Catalog: PROTAC Linker
  • Density: 1.139±0.06 g/cm3(Predicted)
  • Boiling Point: 715.3±60.0 °C(Predicted)
  • Melting Point: N/A
  • Flash Point: N/A
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N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester

N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2100306-76-9
  • MF: C30H54N6O11S
  • MW: 706.85
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Bromo-PEG1-C2-Boc

Bromo-PEG1-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1393330-36-3
  • MF: C9H17BrO3
  • MW: 253.133
  • Catalog: PROTAC Linker
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 285.0±15.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 126.2±20.4 °C
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Biotin-PEG4-methyltetrazine

Biotin-PEG4-methyltetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1835759-81-3
  • MF: C27H39N7O6S
  • MW: 589.71
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Thiol-C9-PEG4

Thiol-C9-PEG4 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 130727-41-2
  • MF: C17H36O4S
  • MW: 336.53000
  • Catalog: PROTAC Linker
  • Density: 0.995 g/mL at 25ºC
  • Boiling Point: 446.5ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: >110ºC
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t-Boc-aminooxy-PEG4-propargyl

Boc-aminooxy-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1895922-77-6
  • MF: C16H29NO7
  • MW: 347.40
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Benzyl-PEG3-amine

Benzyl-PEG3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 86770-75-4
  • MF: C13H21NO3
  • MW: 239.31100
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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t-Boc-N-amido-PEG2-NHS ester

Boc-NH-PEG2-C2-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2183440-73-3
  • MF: C16H26N2O8
  • MW: 374.39
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N,N'-bis-(propargyl-PEG4)-Cy5 (chloride)

N,N'-bis-(propargyl-PEG4)-Cy5 (chloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2107273-08-3
  • MF: C47H63ClN2O8
  • MW: 819.46
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Boc-11-aminoundecanoic acid

Boc-11-aminoundecanoic acid is an Alkyl/ether-based PROTAC linker can be used in the synthesis of MS432 (HY-130602)[1].

  • CAS Number: 10436-25-6
  • MF: C16H31NO4
  • MW: 301.42200
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: 68 °C
  • Flash Point: N/A
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Br-PEG3-ethyl acetate

Br-PEG3-ethyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 308085-31-6
  • MF: C10H19BrO5
  • MW: 299.16
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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H-cis-Hyp-OMe hydrochloride

H-cis-Hyp-OMe hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-cis-Hyp-OMe hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PR

  • CAS Number: 40126-30-5
  • MF: C6H12ClNO3
  • MW: 181.617
  • Catalog: ADC Linker
  • Density: N/A
  • Boiling Point: 282.3ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 124.5ºC
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Mal-amido-PEG7-acid

Mal-amido-PEG7-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2112731-42-5
  • MF: C24H40N2O12
  • MW: 548.58
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Tr-PEG2-OH

Tr-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Tr-PEG2-OH is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

  • CAS Number: 105589-77-3
  • MF: C23H24O3
  • MW: 348.43500
  • Catalog: ADC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Bis-PEG13-PFP ester

Bis-PEG13-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1383567-59-6
  • MF: C42H56F10O17
  • MW: 1022.87
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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HS-PEG3-CH2CH2N3

HS-PEG3-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1347750-79-1
  • MF: C8H17N3O3S
  • MW: 235.30400
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG24-NHS ester

m-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2395839-96-8
  • MF: C54H103NO28
  • MW: 1214.39
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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DBCO-S-S-PEG3-Biotin

DBCO-S-S-PEG3-biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1430408-09-5
  • MF: C42H56N6O8S3
  • MW: 869.124
  • Catalog: PROTAC Linker
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 1194.2±65.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 676.0±34.3 °C
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