PAT-1251 is a potent, selective and oral Lysyl Oxidase-Like 2 (LOXL2) inhibitor, with IC50s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC50s, 0.10, 0.12, and 0.16 μM, respectively); PAT-1251 has entered clinical development with the potential to treat a number of fibrotic diseases.
Methyl 3,4,5-trimethoxybenzoate-d9 is the deuterium labeled Methyl 3,4,5-trimethoxybenzoate[1]. Methyl 3,4,5-trimethoxybenzoate can be synthesized from Gallic acid. Methyl 3,4,5-trimethoxybenzoate is mainly used in the production of Trimethoprim (TMP), Sulfa synergistic intermediates, and many other agents[2].
Dihydrobaicalin is a flavonoid glycoside, which can be isolated from American skullcap (Scutellaria lateriflora L.)[1].
2-Chlorobutanoic acid-d6 is the deuterium labeled 2-Chlorobutanoic acid[1].
N-3-oxo-hexadec-11Z-enoyl-L-Homoserine lactone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Agrostophyllidin is a stilbenoid isolated from the Indian Orchidaceae[1].
LL-37 (37-1) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development[1].
N-(3-Nitro-2-pyridinesulfenyl)-L-aspartic acid β-t-butyl ester is an aspartic acid derivative[1].
FSBA? hydrochloride is a useful reagent for the affinity labeling of adenine nucleotide binding proteins and is mainly applied in the study of purified The labeling and subsequent detection of? these proteins can be blocked by including an excess of MgATP, which competes with FSBA for nucleotidebinding sites[1].
17:0-20:3 PE-d5 is deuterium labeled 17:0-20:3 PE.
4-Dodecylbenzenesulfonic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
2’-Amino-2’-deoxy-5-methylcytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Propylparaben-d7 (Propyl parahydroxybenzoate-d7)is the deuterium labeledPropylparaben(HY-N2026)[1]. Propylparaben (Propyl parahydroxybenzoate) is an antimicrobial preservative which can be produced naturally by plants and bacteria. Propylparaben is prevalently used in cosmetics, pharmaceuticals, and foods. Propylparaben disrupts antral follicle growth and steroidogenic function by altering the cell-cycle, apoptosis, and steroidogenesis pathways. Propylparaben also decreases sperm number and motile activity in rats[2][3][4].
Gly-Asp hydrate is a Glycine (HY-Y0966) derivative[1].
TMPA is an antagonist of nuclear receptor Nur77 and LKB1 interaction.
L-Aspartic acid 4-tert-butyl ester is an aspartic acid derivative[1].
Indacaterol Maleate is an ultra-long-acting β-adrenoceptor agonist.Target: β-adrenoceptorIndacaterol inhibits cAMP production in Chinese hamster ovary cells stably transfected with human β2 adrenoceptors with pEC50 of 8.06. Indacaterol inhibits electrically induced contraction on the electrically stimulated guinea pig trachea in a concentration-dependent manner with pEC50 of 8.23. Indacaterol induces a concentration-dependent inotropic effect with maximal efficacy of 75% in the isolated guinea pig left atrium [1]. Indacaterol reverses the carbachol-induced contraction in a concentration-dependent manner with IC50 of 37 nM in human small airways. Indacaterol concentration dependently reverses the serotonin-induced contraction with IC50 of 10.5 nM in rat small airways. Indacaterol has the highest intrinsic efficacy of 53% in rat small airways and 73% in human small airways [2]. Indacaterol (6.7 μg/kg) inhibits 5-HT-induced bronchoconstriction with a maximal effect of 85% in the conscious guinea pig. Indacaterol (12.5 μg/kg) dose-dependently inhibits methacholine-induced bronchoconstriction with a maximal effect of 85% in the anesthetized rhesus monkey [1].
5-Amino-2-((tert-butoxycarbonyl)amino)-5-oxopentanoic acid is a glutamine derivative[1].
2-Amino-7-propargyl-7,8-dihydro-8-oxo-9-(beta-D-3-deoxy-ribofuranosyl)purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Benzyl lactate is a kind lactate ester[1].
Cyclo(Asp-Asp) is aCyclic dipeptide.
2-Pentylfuran is the compound isolated from steam volatile oils obtained from potatoes at atmospheric pressure[1].
N2-iso-Butyroyl-7'-O-DMT-morpholinoguanine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].
3'-DMTr-dA can be used for the synthesis of nucleotides[1].
Tetrabutylammonium tetrahydroborate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Bancroftinone, a natural product, belongs to the class of alkyl-phenylketones[1].
11(α)-Methoxysaikosaponin F is a triterpenoid saponin isolated from Bupleurum marginatum Wall.ex DC(ZYCH) which is a promising therapeutic for liver fibrosis. 11(α)-Methoxysaikosaponin F has an IC50 of 387.7 nM with viability of hepatic stellate cells-T6 (HSCs-T6). Triterpenoid saponins have numerous targets, important network positions, and strong inhibitory activity[1].
3'Ome-m7GpppAmpG is a cap analogue for mRNA synthesis in vitro[1].
Stemphyperylenol displays a potent antifungal activity against the plant pathogen Alternaria solani with MIC of 1.57 μM.
[18F]-Labeled L-dopa precursor is a precursor for synthesis of 18F-labeled L-dopa extracted from patent WO2014095739A1, example 8[1].