FGFR | Biologically Active Compounds - chemsrc

FGFR (Fibroblast growth factor receptors) are the receptors that bind to members of the fibroblast growth factor family of proteins. Some of these receptors are involved in pathological conditions. A point mutation in FGFR3 can lead to achondroplasia. Five distinct membrane FGFR have been identified in vertebrates and all of them belong to the tyrosine kinase superfamily (FGFR1, FGFR2, FGFR3, FGFR4, FGFR6). The fibroblast growth factor family constitutes one of the most important groups of paracrine factors that act during development. They are responsible for determining certain cells to become mesoderm, for the production of blood vessels, for limb outgrowth, and for the growth and differentiation of numerous cell types.

Trafermin

Trafermin is a recombinant human basic fibroblast growth factor (rhbFGF). Trafermin is a potent FGFR inhibitor. Trafermin improves degree of re-epithelialization. Trafermin can be used in research in skin healing[1].

CAS Number: 131094-16-1
MF: C₁₈H₂₂O₂
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Catalog: FGFR

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FGFR4-IN-12

FGFR4-IN-12 (Compound A34) is a potent inhibitor of FGFR4. FGFR4-IN-12 exhibits improved FGFR4 inhibitory capability and selectivity and excellent anti-proliferative activities against FGFR4-dependent HCC cell lines. FGFR4-IN-12 has the potential for the research of cancer diseases[1].

CAS Number: 2423992-63-4
MF: C₃₄H₃₂Cl₂N₄O₆
MW: 663.55
Catalog: FGFR

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Lenvatinib Mesylate

Lenvatinib mesylate (E7080 mesylate), an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, shows potent antitumor activities[1][2].

CAS Number: 857890-39-2
MF: C₂₂H₂₃ClN₄O₇S
MW: 522.959
Catalog: c-Kit

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