IFNAR | Biologically Active Compounds - chemsrc

The interferon-α/β receptor (IFNAR) is a receptor which binds type I interferons including interferon-α and -β. It is a heteromeric cell surface receptor composed of one chain with two subunits referred to as IFNAR1 and IFNAR2. Upon binding of type I IFNs, IFNAR activates the JAK-STAT signaling pathway. Interferon stimulation classically results in an anti-viral immune response. Type I IFNs share a common receptor consisting of two subunits, IFNAR1 and IFNAR2, which associate upon IFN binding. IFNAR2 is the major ligand binding component of the receptor complex, exhibiting nanomolar affinity to both IFNα and IFNβ subtypes. IFNAR1 and IFNAR2 belong to the class II helical cytokine receptor (hCR) family, which includes the receptor for type II IFN, tissue factor (TF), and IL10Rβ.

Acapatamab

Acapatamab (AMG-160) is a half-life extended bispecific T cell engager (HLE BiTE), including an anti-PSMA binding domain and an anti-CD3 binding domain with Kd values of 14.8 nM and 22.4 nM for hPSMA and hCD3, respectively. Acapatamab can be used in research of cancer[1].

CAS Number: 2314491-93-3
MF:
MW:
Catalog: IFNAR

Density: N/A
Boiling Point: N/A
Melting Point: N/A
Flash Point: N/A

Price

Suppliers

IFN alpha-IFNAR-IN-1

IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR; inhibit MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 uM).IC50 value:Target: IFN alpha-IFNAR interaction inhibitorIFN alpha-IFNAR-IN-1 specifically inhibits MVA-induced IFN-α responses by BM-pDCs. IFN alpha-IFNAR-IN-1 inhibited the IFN-α responses that were elicited after treatment with CpG2216, stimulation with poly(I:C), and infection with VSV-M2, whereas the total IL-12 production was notably less affected under those conditions. IFN alpha-IFNAR-IN-1 exerts immunosuppressive activity by the direct interaction with IFN-α [1].

CAS Number: 844882-93-5
MF: C₁₈H₁₇NS
MW: 279.399
Catalog: IFNAR

Density: 1.2±0.1 g/cm3
Boiling Point: 419.4±28.0 °C at 760 mmHg
Melting Point: N/A
Flash Point: 207.5±24.0 °C

Price

Suppliers

RIG012

RIG012 is a potent RIG-I inhibitor with an IC50 of 0.71 μM using the NADH-coupled ATPase assay. RIG012 inhibits IFN-β and ISG hRsad2 expression[1].

CAS Number: 2642218-43-5
MF: C₂₃H₂₁NO₃
MW: 359.42
Catalog: IFNAR

Density: N/A
Boiling Point: N/A
Melting Point: N/A
Flash Point: N/A

Price

Suppliers

Dazukibart

Dazukibart is a mouse-derived, humanized IgG1κ antibody targeting interferon beta 1 (IFNB1)[1].

CAS Number: 2639474-65-8
MF:
MW:
Catalog: IFNAR

Density: N/A
Boiling Point: N/A
Melting Point: N/A
Flash Point: N/A

Price

Suppliers