AT2R antagonist 1
Modify Date: 2025-08-25 13:52:50
AT2R antagonist 1 structure
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Common Name | AT2R antagonist 1 | ||
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| CAS Number | 2709031-17-2 | Molecular Weight | 490.64 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H30N4O4S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AT2R antagonist 1AT2R antagonist 1 (compound 21) is a potent and high selective AT2R (angiotensin II AT2 receptor) ligand. AT2R antagonist 1 exhibits a fair AT2R affinity, with a Ki of 29 nM. AT2R antagonist 1 also inhibits common drug-metabolizing CYP enzymes. AT2R antagonist 1 shows high stability in human, rat and mouse liver microsomes[1]. |
| Name | AT2R antagonist 1 |
|---|
| Description | AT2R antagonist 1 (compound 21) is a potent and high selective AT2R (angiotensin II AT2 receptor) ligand. AT2R antagonist 1 exhibits a fair AT2R affinity, with a Ki of 29 nM. AT2R antagonist 1 also inhibits common drug-metabolizing CYP enzymes. AT2R antagonist 1 shows high stability in human, rat and mouse liver microsomes[1]. |
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| Related Catalog | |
| Target |
Ki: 29 nM (AT2R), 1000 nM (AT1R)[1] |
| In Vitro | AT2R antagonist 1 (compound 21) exhibits a negligible inhibition of CYP 3A (5%) and a very low tendency to inhibit CYP 2D6 (12%), 2C8 (26%), 2C9 (23%) and 2B6 (24%)[1]. |
| References |
| Molecular Formula | C23H30N4O4S2 |
|---|---|
| Molecular Weight | 490.64 |