1191031-97-6
1191031-97-6 structure
- Name: CCR10 antagonist 1
- Chemical Name: CCR10 antagonist 1
- CAS Number: 1191031-97-6
- Molecular Formula: C19H24Cl2N6O5S
- Molecular Weight: 519.398
- Create Date: 2020-01-14 01:01:04
- Modify Date: 2024-04-09 20:37:03
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CCR10 antagonist 1 is a potent, selective CCR10 antagonist with IC50 of 690 nM; demonstrates functional CCR1 antagonism by inhibiting the CCL27 dependent chemotaxis of Ba/F3 cells stably transfected with human CCR10 with an IC50 of 53 nM, exhibits no antagonism of murine CCL27 dependent Ca2+ flux in CHO-K cells stably transfected with murine CCR10 at 20 uM.
| Name | CCR10 antagonist 1 |
|---|
| Description | CCR10 antagonist 1 is a potent, selective CCR10 antagonist with IC50 of 690 nM; demonstrates functional CCR1 antagonism by inhibiting the CCL27 dependent chemotaxis of Ba/F3 cells stably transfected with human CCR10 with an IC50 of 53 nM, exhibits no antagonism of murine CCL27 dependent Ca2+ flux in CHO-K cells stably transfected with murine CCR10 at 20 uM. |
|---|---|
| References | References 1. Abeywardane A, et al. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5277-5283. View Related Products by Target Chemokine Receptor (CCR and CXCR) |
| Molecular Formula | C19H24Cl2N6O5S |
|---|---|
| Molecular Weight | 519.398 |