Amino-PEG4-CH2COOH
Modify Date: 2025-09-11 17:29:56
Amino-PEG4-CH2COOH structure
|
Common Name | Amino-PEG4-CH2COOH | ||
|---|---|---|---|---|
| CAS Number | 195071-49-9 | Molecular Weight | 251.27700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C10H21NO6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Amino-PEG4-CH2COOHAmino-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Amino-PEG4-CH2COOH is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
| Name | 2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]acetic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Amino-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Amino-PEG4-CH2COOH is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
|---|---|
| Related Catalog | |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
| Molecular Formula | C10H21NO6 |
|---|---|
| Molecular Weight | 251.27700 |
| Exact Mass | 251.13700 |
| PSA | 100.24000 |
| InChIKey | NPRAKTLKDKKZAV-UHFFFAOYSA-N |
| SMILES | NCCOCCOCCOCCOCC(=O)O |
| Hazard Codes | Xi |
|---|
|
~82%
Amino-PEG4-CH2COOH CAS#:195071-49-9 |
| Literature: Bogdan, Niculina D.; Matache, Mihaela; Meier, Veronika M.; Dobrotae, Cristian; Dumitru, Ioana; Roiban, Gheorghe D.; Funeriu, Daniel P. Chemistry - A European Journal, 2010 , vol. 16, # 7 p. 2170 - 2180 |
| 14-amino-3,6,9,12-tetraoxa-1-tetradecanoic acid |
| 3,6,9,12-Tetraoxatetradecanoic acid,14-amino |