195071-49-9
195071-49-9 structure
- Name: Amino-PEG4-CH2COOH
- Chemical Name: 2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]acetic acid
- CAS Number: 195071-49-9
- Molecular Formula: C10H21NO6
- Molecular Weight: 251.27700
- Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
- Create Date: 2017-08-19 16:52:10
- Modify Date: 2025-09-11 17:29:56
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Amino-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Amino-PEG4-CH2COOH is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
| Name | 2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]acetic acid |
|---|---|
| Synonyms |
14-amino-3,6,9,12-tetraoxa-1-tetradecanoic acid
3,6,9,12-Tetraoxatetradecanoic acid,14-amino |
| Description | Amino-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Amino-PEG4-CH2COOH is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
|---|---|
| Related Catalog | |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
| Molecular Formula | C10H21NO6 |
|---|---|
| Molecular Weight | 251.27700 |
| Exact Mass | 251.13700 |
| PSA | 100.24000 |
| Hazard Codes | Xi |
|---|
|
~82%
195071-49-9 |
| Literature: Bogdan, Niculina D.; Matache, Mihaela; Meier, Veronika M.; Dobrotae, Cristian; Dumitru, Ioana; Roiban, Gheorghe D.; Funeriu, Daniel P. Chemistry - A European Journal, 2010 , vol. 16, # 7 p. 2170 - 2180 |
