Amino-PEG4-(CH2)3CO2H

Modify Date: 2024-01-16 19:27:59

Amino-PEG4-(CH2)3CO2H Structure
Amino-PEG4-(CH2)3CO2H structure
Common Name Amino-PEG4-(CH2)3CO2H
CAS Number 144598-03-8 Molecular Weight 279.330
Density 1.1±0.1 g/cm3 Boiling Point 421.7±40.0 °C at 760 mmHg
Molecular Formula C12H25NO6 Melting Point N/A
MSDS N/A Flash Point 208.9±27.3 °C

 Use of Amino-PEG4-(CH2)3CO2H


Amino-PEG4-(CH2)3CO2H is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Amino-PEG4-(CH2)3CO2H
Synonym More Synonyms

 Amino-PEG4-(CH2)3CO2H Biological Activity

Description Amino-PEG4-(CH2)3CO2H is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 421.7±40.0 °C at 760 mmHg
Molecular Formula C12H25NO6
Molecular Weight 279.330
Flash Point 208.9±27.3 °C
Exact Mass 279.168182
LogP -1.71
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.469

 Safety Information

Hazard Codes Xi

 Synonyms

1-Amino-3,6,9,12-tetraoxahexadecan-16-oic acid
3,6,9,12-Tetraoxahexadecan-16-oic acid, 1-amino-
MFCD27977500
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