Cbz-NH-PEG5-CH2COOH

Modify Date: 2024-01-14 11:51:59

Cbz-NH-PEG5-CH2COOH Structure
Cbz-NH-PEG5-CH2COOH structure
Common Name Cbz-NH-PEG5-CH2COOH
CAS Number 1449390-66-2 Molecular Weight 429.461
Density 1.2±0.1 g/cm3 Boiling Point 590.4±50.0 °C at 760 mmHg
Molecular Formula C20H31NO9 Melting Point N/A
MSDS N/A Flash Point 310.9±30.1 °C

 Use of Cbz-NH-PEG5-CH2COOH


Cbz-NH-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Z-NH-5(ethylene glycol)-acetic acid
Synonym More Synonyms

 Cbz-NH-PEG5-CH2COOH Biological Activity

Description Cbz-NH-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 590.4±50.0 °C at 760 mmHg
Molecular Formula C20H31NO9
Molecular Weight 429.461
Flash Point 310.9±30.1 °C
Exact Mass 429.199890
LogP -0.27
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.508

 Synonyms

3-Oxo-1-phenyl-2,7,10,13,16,19-hexaoxa-4-azahenicosan-21-oic acid
2,7,10,13,16,19-Hexaoxa-4-azaheneicosan-21-oic acid, 3-oxo-1-phenyl-