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165454-06-8

165454-06-8 structure
165454-06-8 structure
  • Name: Cbz-NH-PEG2-CH2COOH
  • Chemical Name: 2-[2-[2-(phenylmethoxycarbonylamino)ethoxy]ethoxy]acetic acid
  • CAS Number: 165454-06-8
  • Molecular Formula: C14H19NO6
  • Molecular Weight: 297.30400
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-20 08:56:03
  • Modify Date: 2024-01-09 20:34:38
  • Cbz-NH-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 2-[2-[2-(phenylmethoxycarbonylamino)ethoxy]ethoxy]acetic acid
Synonyms AmbotzZAA1186
2-(2-(2-Benzyloxycarbonylaminoethoxy)ethoxy)acetic acid
3-Oxo-1-phenyl-2,7,10-trioxa-4-azadodecan-12-oic acid
8-Benzyloxycarbonylamino-3,6-dioxaoctanoic acid
Description Cbz-NH-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Boiling Point 506.6±45.0°C at 760 mmHg
Molecular Formula C14H19NO6
Molecular Weight 297.30400
Exact Mass 297.12100
PSA 97.58000
LogP 1.23500
HS Code 2934999090
HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%