Cbz-NH-PEG5-CH2COOH

Names

[ Name ]:
Cbz-NH-PEG5-CH2COOH

[Synonym ]:
3-Oxo-1-phenyl-2,7,10,13,16,19-hexaoxa-4-azahenicosan-21-oic acid
2,7,10,13,16,19-Hexaoxa-4-azaheneicosan-21-oic acid, 3-oxo-1-phenyl-

Biological Activity

[Description]:

Cbz-NH-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
590.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₃₁NO₉

[ Molecular Weight ]:
429.461

[ Flash Point ]:
310.9±30.1 °C

[ Exact Mass ]:
429.199890

[ LogP ]:
-0.27

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.508

Cbz-NH-PEG5-CH2COOH

Names

Biological Activity

Chemical & Physical Properties

Related Compounds