Cbz-NH-PEG2-CH2COOH

Names

[ Name ]:
Cbz-NH-PEG2-CH2COOH

[Synonym ]:
AmbotzZAA1186
2-(2-(2-Benzyloxycarbonylaminoethoxy)ethoxy)acetic acid
3-Oxo-1-phenyl-2,7,10-trioxa-4-azadodecan-12-oic acid
8-Benzyloxycarbonylamino-3,6-dioxaoctanoic acid

Biological Activity

[Description]:

Cbz-NH-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Boiling Point ]:
506.6±45.0°C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₉NO₆

[ Molecular Weight ]:
297.30400

[ Exact Mass ]:
297.12100

[ PSA ]:
97.58000

[ LogP ]:
1.23500

Safety Information

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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