Cbz-NH-PEG5-C2-acid

Modify Date: 2024-01-04 15:00:21

Cbz-NH-PEG5-C2-acid Structure
Cbz-NH-PEG5-C2-acid structure
Common Name Cbz-NH-PEG5-C2-acid
CAS Number 1347750-74-6 Molecular Weight 443.488
Density 1.2±0.1 g/cm3 Boiling Point 599.4±50.0 °C at 760 mmHg
Molecular Formula C21H33NO9 Melting Point N/A
MSDS N/A Flash Point 316.3±30.1 °C

 Use of Cbz-NH-PEG5-C2-acid


Cbz-NH-PEG5-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Cbz-N-amido-PEG5-acid
Synonym More Synonyms

 Cbz-NH-PEG5-C2-acid Biological Activity

Description Cbz-NH-PEG5-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 599.4±50.0 °C at 760 mmHg
Molecular Formula C21H33NO9
Molecular Weight 443.488
Flash Point 316.3±30.1 °C
Exact Mass 443.215546
LogP 0.11
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.507

 Synonyms

CBZ-N-AMIDO-PEG5-COOH
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