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1334177-87-5

1334177-87-5 structure
1334177-87-5 structure
  • Name: Cbz-NH-PEG8-C2-acid
  • Chemical Name: 3-Oxo-1-phenyl-2,7,10,13,16,19,22,25,28-nonaoxa-4-azahentriacontan-31-oic acid
  • CAS Number: 1334177-87-5
  • Molecular Formula: C27H45NO12
  • Molecular Weight: 575.646
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-27 09:14:00
  • Modify Date: 2024-01-09 16:51:50
  • Cbz-NH-PEG8-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 3-Oxo-1-phenyl-2,7,10,13,16,19,22,25,28-nonaoxa-4-azahentriacontan-31-oic acid
Synonyms 3-Oxo-1-phenyl-2,7,10,13,16,19,22,25,28-nonaoxa-4-azahentriacontan-31-oic acid
2,7,10,13,16,19,22,25,28-Nonaoxa-4-azahentriacontan-31-oic acid, 3-oxo-1-phenyl-
Description Cbz-NH-PEG8-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.2±0.1 g/cm3
Boiling Point 681.2±55.0 °C at 760 mmHg
Molecular Formula C27H45NO12
Molecular Weight 575.646
Flash Point 365.8±31.5 °C
Exact Mass 575.294189
LogP -0.96
Vapour Pressure 0.0±2.2 mmHg at 25°C
Index of Refraction 1.498