Cbz-NH-PEG3-CH2COOH

Modify Date: 2024-04-05 14:56:26

Cbz-NH-PEG3-CH2COOH Structure
Cbz-NH-PEG3-CH2COOH structure
Common Name Cbz-NH-PEG3-CH2COOH
CAS Number 462100-05-6 Molecular Weight 341.356
Density 1.2±0.1 g/cm3 Boiling Point 534.1±50.0 °C at 760 mmHg
Molecular Formula C16H23NO7 Melting Point N/A
MSDS N/A Flash Point 276.8±30.1 °C

 Use of Cbz-NH-PEG3-CH2COOH


Cbz-NH-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 3-Oxo-1-phenyl-2,7,10,13-tetraoxa-4-azapentadecan-15-oic acid
Synonym More Synonyms

 Cbz-NH-PEG3-CH2COOH Biological Activity

Description Cbz-NH-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 534.1±50.0 °C at 760 mmHg
Molecular Formula C16H23NO7
Molecular Weight 341.356
Flash Point 276.8±30.1 °C
Exact Mass 341.147461
PSA 106.81000
LogP 0.44
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.519

 Synonyms

2,7,10,13-Tetraoxa-4-azapentadecan-15-oic acid, 3-oxo-1-phenyl-
3-Oxo-1-phenyl-2,7,10,13-tetraoxa-4-azapentadecan-15-oic acid