DHODH-IN-3

Modify Date: 2024-04-05 20:24:05

DHODH-IN-3 structure	Common Name	DHODH-IN-3
	CAS Number	1148126-04-8	Molecular Weight	312.75
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₃ClN₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of DHODH-IN-3

DHODH-IN-3 (compound 3) is a potent inhibitor of Human Dihydroorotate Dehydrogenases (HsDHODH) with an IC50 value of 261 nM. DHODH-IN-3 binds to the the ubiquinone binding cavities in DHODH with a Kiapp of 32 nM. DHODH-IN-3 has the potential for malaria treatment[1].

Name	DHODH-IN-3

Description	DHODH-IN-3 (compound 3) is a potent inhibitor of Human Dihydroorotate Dehydrogenases (HsDHODH) with an IC50 value of 261 nM. DHODH-IN-3 binds to the the ubiquinone binding cavities in DHODH with a Kiapp of 32 nM. DHODH-IN-3 has the potential for malaria treatment[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Metabolic Enzyme/Protease >> Lactate Dehydrogenase
Target	IC50: 261 nM (HsDHODH)[1]
In Vitro	DHODH-IN-3 (compound 3) show good inhibitory effects on HsDHODH with IC50 value of 261 nM. It binds to HsDHODH with a Kiapp value of 32 nM[1].
References	[1]. Davies M, et al. Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases.J Med Chem. 2009 May 14;52(9):2683-93.

Molecular Formula	C₁₇H₁₃ClN₂O₂
Molecular Weight	312.75

DC Chemicals Limited
China
Product Name: DHODH-IN-3
Price:
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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