DHODH-IN-3

Names

[ Name ]:
DHODH-IN-3

Biological Activity

[Description]:

DHODH-IN-3 (compound 3) is a potent inhibitor of Human Dihydroorotate Dehydrogenases (HsDHODH) with an IC50 value of 261 nM. DHODH-IN-3 binds to the the ubiquinone binding cavities in DHODH with a Kiapp of 32 nM. DHODH-IN-3 has the potential for malaria treatment[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

Signaling Pathways >> Metabolic Enzyme/Protease >> Lactate Dehydrogenase

[Target]

IC50: 261 nM (HsDHODH)[1]

[In Vitro]

DHODH-IN-3 (compound 3) show good inhibitory effects on HsDHODH with IC50 value of 261 nM. It binds to HsDHODH with a Kiapp value of 32 nM[1].

[References]

[1]. Davies M, et al. Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases.J Med Chem. 2009 May 14;52(9):2683-93.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₃ClN₂O₂

[ Molecular Weight ]:
312.75

DHODH-IN-3

Names

Biological Activity

Chemical & Physical Properties

Related Compounds