DHODH-IN-11
Names
[ CAS No. ]:
1263303-95-2
[ Name ]:
DHODH-IN-11
Biological Activity
[Description]:
DHODH-IN-11 (Compound 14b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03[1].
[Related Catalog]:
[Target]
pKa: 5.03 (DHODH)[1]
[In Vitro]
Designed a compound structurally related to Leflunomide, containing the furazan ring (Compound 14a), is designed. Compound 14a undergo ring 4 scission under physiological pH conditions to afford the corresponding cyano-oximes DHODH-IN-11 (Compound 14b). DHODH-IN-14 has been assayed as a DHODH inhibitor; its low potency is probably due to the unfavourable stereochemistry of the oxime substructure[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C15H11N3O2
[ Molecular Weight ]:
265.27
Safety Information
[ Hazard Codes ]:
Xi