DHODH-IN-17

Modify Date: 2024-01-09 19:43:15

DHODH-IN-17 Structure
DHODH-IN-17 structure
Common Name DHODH-IN-17
CAS Number 16344-26-6 Molecular Weight 248.67
Density N/A Boiling Point N/A
Molecular Formula C12H9ClN2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DHODH-IN-17


DHODH-IN-17, a 2-anilino nicotinic acid, is a human DHODH inhibitor (IC50=0.40 μM). DHODH-IN-17 can be used for theresearch of acute myeloid leukemia (AML)[1].

 Names

Name 2-(4-chloroanilino)pyridine-3-carboxylic acid
Synonym More Synonyms

 DHODH-IN-17 Biological Activity

Description DHODH-IN-17, a 2-anilino nicotinic acid, is a human DHODH inhibitor (IC50=0.40 μM). DHODH-IN-17 can be used for theresearch of acute myeloid leukemia (AML)[1].
Related Catalog
Target

IC50: 0.4 μM (DHODH)[1]

In Vitro DHODH-IN-17, a 2-anilino nicotinic acid, is a human DHODH inhibitor with an IC50 value of 0.40 μM[1].
References

[1]. Lewis TA, et al. Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ACS Med Chem Lett. 2016;7(12):1112-1117.

 Chemical & Physical Properties

Molecular Formula C12H9ClN2O2
Molecular Weight 248.67
Exact Mass 248.03500
PSA 62.22000
LogP 3.24980

 Synthetic Route

~99%

DHODH-IN-17 Structure

DHODH-IN-17

CAS#:16344-26-6

Literature: Kamal, Ahmed; Srikanth; Naseer Ahmed Khan; Ashraf, Md.; Kashi Reddy; Sultana, Farheen; Kaur, Tandeep; Chashoo, Gousia; Suri, Nitasha; Sehar, Irum; Wani, Zahoor A.; Saxena, Arpita; Sharma, Parduman R.; Bhushan, Shashi; Mondhe, Dilip M.; Saxena, Ajit K. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 23 p. 7136 - 7150

~92%

DHODH-IN-17 Structure

DHODH-IN-17

CAS#:16344-26-6

Literature: Li, Zhenghua; Xiao, Shangyou; Liang, Ronghui; Xia, Zhining Research on Chemical Intermediates, 2012 , vol. 38, # 7 p. 1691 - 1697

~%

DHODH-IN-17 Structure

DHODH-IN-17

CAS#:16344-26-6

Literature: Kamal, Ahmed; Srikanth, Yellamelli Valli Venkata; Khan, Mohammed Naseer Ahmed; Ashraf, Mohammed; Sehar, Irum; Chashoo, Gousia; Sharma, Parduman Raj; Dar, Abid Hamid; Shashi, Bhushan; Singh, Shashank Kumar; Mondhe, Dilip Manikrao; Saxena, Ajit Kumar Patent: US2013/324734 A1, 2013 ;

~%

DHODH-IN-17 Structure

DHODH-IN-17

CAS#:16344-26-6

Literature: Kamal, Ahmed; Srikanth, Yellamelli Valli Venkata; Khan, Mohammed Naseer Ahmed; Ashraf, Mohammed; Sehar, Irum; Chashoo, Gousia; Sharma, Parduman Raj; Dar, Abid Hamid; Shashi, Bhushan; Singh, Shashank Kumar; Mondhe, Dilip Manikrao; Saxena, Ajit Kumar Patent: US2013/324734 A1, 2013 ;

 Synonyms

2-[(4-chlorophenyl)amino]-3-pyridinecarboxylic acid
HMS2655G09
2-(4-chloro-anilino)-nicotinic acid
2-(4-Chloro-phenylamino)-nicotinic acid
2-(p-Chloranilino)-nicotinsaeure
2-[(4-chlorophenyl)amino]pyridine-3-carboxylic acid
Top Suppliers:I want be here


Get all suppliers and price by the below link:

DHODH-IN-17 suppliers


Price: ¥800/5 mg

Reference only. check more DHODH-IN-17 price