1263303-93-0
1263303-93-0 structure
- Name: DHODH-IN-12
- Chemical Name: DHODH-IN-12
- CAS Number: 1263303-93-0
- Molecular Formula: C10H9N3O2
- Molecular Weight: 203.20
- Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
- Create Date: 2020-04-08 19:21:39
- Modify Date: 2025-08-26 17:46:44
-
DHODH-IN-12 (Compound 12b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07[1].
| Name | DHODH-IN-12 |
|---|
| Description | DHODH-IN-12 (Compound 12b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07[1]. |
|---|---|
| Related Catalog | |
| Target |
pKa: 5.07 (DHODH)[1] |
| In Vitro | Designed a compound structurally related to Leflunomide, containing the furazan ring (Compound 12a), is designed. Compound 12a undergo ring 4 scission under physiological pH conditions to afford the corresponding cyano-oximes DHODH-IN-12 (Compound 12b). DHODH-IN-12 has been assayed as a DHODH inhibitor; its low potency is probably due to the unfavourable stereochemistry of the oxime substructure[1]. |
| References |
| Molecular Formula | C10H9N3O2 |
|---|---|
| Molecular Weight | 203.20 |