DHODH-IN-12

Modify Date: 2024-01-10 21:20:35

DHODH-IN-12 structure	Common Name	DHODH-IN-12
	CAS Number	1263303-93-0	Molecular Weight	203.20
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₀H₉N₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of DHODH-IN-12

DHODH-IN-12 (Compound 12b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07[1].

Name	DHODH-IN-12

Description	DHODH-IN-12 (Compound 12b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Metabolic Enzyme/Protease >> Lactate Dehydrogenase Research Areas >> Inflammation/Immunology
Target	pKa: 5.07 (DHODH)[1]
In Vitro	Designed a compound structurally related to Leflunomide, containing the furazan ring (Compound 12a), is designed. Compound 12a undergo ring 4 scission under physiological pH conditions to afford the corresponding cyano-oximes DHODH-IN-12 (Compound 12b). DHODH-IN-12 has been assayed as a DHODH inhibitor; its low potency is probably due to the unfavourable stereochemistry of the oxime substructure[1].
References	[1]. Giorgis M, et al. 1,2,5-Oxadiazole analogues of leflunomide and related compounds. Eur J Med Chem. 2011 Jan;46(1):383-92.

Molecular Formula	C₁₀H₉N₃O₂
Molecular Weight	203.20

DC Chemicals Limited
China
Product Name: DHODH-IN-12
Price:
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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