DHODH-IN-12
Names
[ CAS No. ]:
1263303-93-0
[ Name ]:
DHODH-IN-12
Biological Activity
[Description]:
DHODH-IN-12 (Compound 12b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07[1].
[Related Catalog]:
[Target]
pKa: 5.07 (DHODH)[1]
[In Vitro]
Designed a compound structurally related to Leflunomide, containing the furazan ring (Compound 12a), is designed. Compound 12a undergo ring 4 scission under physiological pH conditions to afford the corresponding cyano-oximes DHODH-IN-12 (Compound 12b). DHODH-IN-12 has been assayed as a DHODH inhibitor; its low potency is probably due to the unfavourable stereochemistry of the oxime substructure[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C10H9N3O2
[ Molecular Weight ]:
203.20