2450341-39-4
2450341-39-4 structure
- Name: DHODH-IN-21
- Chemical Name: DHODH-IN-21
- CAS Number: 2450341-39-4
- Molecular Formula: C20H19ClF4N6O4
- Molecular Weight: 518.85
- Catalog: Research Areas Cancer
- Create Date: 2022-09-11 11:39:15
- Modify Date: 2024-04-03 20:53:53
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DHODH-IN-21 (compound 19) is an orally active selective dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 value of 1.1 nM. DHODH-IN-21 has anticancer activity and can be used in studies of acute myeloid leukaemia (AML)[1].
| Name | DHODH-IN-21 |
|---|
| Description | DHODH-IN-21 (compound 19) is an orally active selective dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 value of 1.1 nM. DHODH-IN-21 has anticancer activity and can be used in studies of acute myeloid leukaemia (AML)[1]. |
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| Related Catalog | |
| Target |
Mouse DHODH:140 nM (IC50) Rat DHODH:1580 nM (IC50) Dog DHODH:8.5 nM (IC50) Monkey DHODH:1.6 nM (IC50) |
| In Vitro | DHODH-IN-21 (compound 19) inhibits the proliferation of MOLM-13 and THP-1 cells with the IC50 values of 2.0 nM and 5.0 nM, respectively[1]. |
| In Vivo | DHODH-IN-21 (compound 19) (p.o., 10 or 20 mg/kg, everyday, 5 days) inhibits tumor growth in a dose-dependent manner but no effect on body weight in female NSG mice[1]. Animal Model: Human MOLM-13 AML xenograft model in female NSG mice[1] Dosage: 10, 20 mg/kg Administration: Oral administration; everyday; 5 days Result: Inhibited tumor volume size by 44% and 60% at 10 mg/kg and 20 mg/kg respectively. Animal Model: Mouse, rat[1] Dosage: Administration: 2 mg/kg i.v. or 10 mg/kg p.o. Result: The pharmacokinetic parameters of DHODH-IN-21 (compound 19) Parameter Mouse Rat CL (mL/min/kg) 11 32 Vdss (L/kg) 1.3 2.3 t1/2(h) 2.3 2.0 Cmax (ng/mL) 4047 1713 tmax(h) 0.42 1.7 AUC0→inf(h•ng/mL) 16,066 9214 F% 103 167 |
| References |
| Molecular Formula | C20H19ClF4N6O4 |
|---|---|
| Molecular Weight | 518.85 |