DHODH-IN-17

Names

[ Name ]:
DHODH-IN-17

[Synonym ]:
2-[(4-chlorophenyl)amino]-3-pyridinecarboxylic acid
HMS2655G09
2-(4-chloro-anilino)-nicotinic acid
2-(4-Chloro-phenylamino)-nicotinic acid
2-(p-Chloranilino)-nicotinsaeure
2-[(4-chlorophenyl)amino]pyridine-3-carboxylic acid

Biological Activity

[Description]:

DHODH-IN-17, a 2-anilino nicotinic acid, is a human DHODH inhibitor (IC50=0.40 μM). DHODH-IN-17 can be used for theresearch of acute myeloid leukemia (AML)[1].

[Related Catalog]:

Research Areas >> Cancer

[Target]

IC50: 0.4 μM (DHODH)[1]

[In Vitro]

DHODH-IN-17, a 2-anilino nicotinic acid, is a human DHODH inhibitor with an IC50 value of 0.40 μM[1].

[References]

[1]. Lewis TA, et al. Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ACS Med Chem Lett. 2016;7(12):1112-1117.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₉ClN₂O₂

[ Molecular Weight ]:
248.67

[ Exact Mass ]:
248.03500

[ PSA ]:
62.22000

[ LogP ]:
3.24980

Synthetic Route

Click to get detail synthetic route

Related Compounds

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