DHODH-IN-7

Modify Date: 2024-01-10 12:38:32

DHODH-IN-7 structure	Common Name	DHODH-IN-7
	CAS Number	2029049-77-0	Molecular Weight	390.40
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₂₁F₃N₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of DHODH-IN-7

DHODH-IN-7 is a human dihydroorotate dehydrogenase (DHODH) inhibitor, with an IC50 of 0.91 μM. DHODH-IN-7 induces differentiation in acute myeloid leukemia[1].

Name	DHODH-IN-7

Description	DHODH-IN-7 is a human dihydroorotate dehydrogenase (DHODH) inhibitor, with an IC50 of 0.91 μM. DHODH-IN-7 induces differentiation in acute myeloid leukemia[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Metabolic Enzyme/Protease >> Lactate Dehydrogenase
In Vitro	The lysozyme-GFPER-HoxA9 murine cell line (ER-HOX-GFP) and the THP1 and U937 human AML cell lines were cultured with compounds in a 4-day differentiation assay. DHODH-IN-7 shows EC50s of 3.6, 2.7, and 2.5 μM for ER-HOX-GFP, THP1 and U937 human AML cell lines, respectively[1].
References	[1]. Lewis TA, et al. Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ACS Med Chem Lett. 2016 Sep 28;7(12):1112-1117.

Molecular Formula	C₂₁H₂₁F₃N₂O₂
Molecular Weight	390.40

Hazard Codes	Xi

DC Chemicals Limited
China
Product Name: DHODH-IN-7
Price:
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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