DHODH-IN-7

Modify Date: 2025-08-25 16:21:26

DHODH-IN-7 Structure
DHODH-IN-7 structure
Common Name DHODH-IN-7
CAS Number 2029049-77-0 Molecular Weight 390.40
Density N/A Boiling Point N/A
Molecular Formula C21H21F3N2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DHODH-IN-7


DHODH-IN-7 is a human dihydroorotate dehydrogenase (DHODH) inhibitor, with an IC50 of 0.91 μM. DHODH-IN-7 induces differentiation in acute myeloid leukemia[1].

 Names

Name DHODH-IN-7

 DHODH-IN-7 Biological Activity

Description DHODH-IN-7 is a human dihydroorotate dehydrogenase (DHODH) inhibitor, with an IC50 of 0.91 μM. DHODH-IN-7 induces differentiation in acute myeloid leukemia[1].
Related Catalog
In Vitro The lysozyme-GFPER-HoxA9 murine cell line (ER-HOX-GFP) and the THP1 and U937 human AML cell lines were cultured with compounds in a 4-day differentiation assay. DHODH-IN-7 shows EC50s of 3.6, 2.7, and 2.5 μM for ER-HOX-GFP, THP1 and U937 human AML cell lines, respectively[1].
References

[1]. Lewis TA, et al. Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ACS Med Chem Lett. 2016 Sep 28;7(12):1112-1117.

 Chemical & Physical Properties

Molecular Formula C21H21F3N2O2
Molecular Weight 390.40

 Safety Information

Hazard Codes Xi
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