DHODH-IN-13
Modify Date: 2025-08-25 23:29:14
DHODH-IN-13 structure
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Common Name | DHODH-IN-13 | ||
|---|---|---|---|---|
| CAS Number | 1364791-86-5 | Molecular Weight | 273.17 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C10H6F3N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DHODH-IN-13DHODH-IN-13 (Compound 7a) is a hydroxyfurazan analog of A771726. DHODH-IN-13 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 4.3 μM for rat liver DHODH. DHODH-IN-13 can be used for rheumatoid arthritis[1]. |
| Name | DHODH-IN-13 |
|---|
| Description | DHODH-IN-13 (Compound 7a) is a hydroxyfurazan analog of A771726. DHODH-IN-13 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 4.3 μM for rat liver DHODH. DHODH-IN-13 can be used for rheumatoid arthritis[1]. |
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| Related Catalog | |
| Target |
IC50: 4.3 μM for (Rat liver DHODH)[1] |
| In Vitro | DHODH-IN-13 (Compound 7a) is a hydroxyfurazan analog of A771726 and is stable under physiological conditions. When DHODH-IN-13 is docked in silico at the DHODH active site, a BQN-like pose is obtained with the deprotonated furazan hydroxyl facing Arg136 instead of Tyr356, thus effectively mimicking the carboxyl group of BQN and related compounds[1]. |
| References |
| Molecular Formula | C10H6F3N3O3 |
|---|---|
| Molecular Weight | 273.17 |
| InChIKey | SYZRMPPEMZWUSK-UHFFFAOYSA-N |
| SMILES | O=C(Nc1ccc(C(F)(F)F)cc1)c1no[nH]c1=O |