DHODH-IN-1

Modify Date: 2024-01-29 07:26:40

DHODH-IN-1 structure	Common Name	DHODH-IN-1
	CAS Number	1800296-63-2	Molecular Weight	403.40
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₂₀F₃N₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of DHODH-IN-1

DHODH-IN-1 (compound 18d) is a potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 25 nM. DHODH-IN-1 is an inhibitor of pyrimidine biosynthesis pathway[1].

Name	DHODH-IN-1

Description	DHODH-IN-1 (compound 18d) is a potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 25 nM. DHODH-IN-1 is an inhibitor of pyrimidine biosynthesis pathway[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Metabolic Enzyme/Protease >> Lactate Dehydrogenase
Target	IC50: 25 nM (DHODH)[1]
In Vitro	DHODH-IN-1 (compound 18d) strongly inhibits Jurkat cells proliferation (IC50=0.02 μM)[1]. DHODH-IN-1 (4, 20, 100 nM) blocks the measles virus replication in cells[1]. DHODH-IN-1 (0.008, 0.04, 0.2, 1, 5 μM) increases the expression of an ISRE-luciferase reporter gene when transfecting cells with ssRNA molecules[1]. Cell Proliferation Assay[1] Cell Line: Jurkat cells Concentration: 0.00001, 0.0001, 0.001, 0.01, 0.1, 1, 10 μM Incubation Time: 72 hours Result: Strongly inhibited Jurkat cells proliferation (IC50=0.02 μM).
In Vivo	DHODH-IN-1 (compound 18d) has a t1/2 of 27–41 min[1].
References	[1]. Lucas-Hourani M, et al.Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH).J Med Chem. 2015 Jul 23;58(14):5579-98.

Molecular Formula	C₂₁H₂₀F₃N₃O₂
Molecular Weight	403.40

DC Chemicals Limited
China
Product Name: DHODH-IN-1
Price:
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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