HDAC1/MAO-B-IN-1
Modify Date: 2025-09-07 05:45:36
HDAC1/MAO-B-IN-1 structure
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Common Name | HDAC1/MAO-B-IN-1 | ||
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| CAS Number | 2759855-37-1 | Molecular Weight | 328.79 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H17ClN2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HDAC1/MAO-B-IN-1HDAC1/MAO-B-IN-1 is a potent, selective and cross the blood-brain barrier HDAC1/MAO-B inhibitor with IC50 values of 21.4 nM and 99.0 nM for HDAC1 and MAO-B, respectively. HDAC1/MAO-B-IN-1 has the potential for the research of Alzheimer’s disease[1]. |
| Name | HDAC1/MAO-B-IN-1 |
|---|
| Description | HDAC1/MAO-B-IN-1 is a potent, selective and cross the blood-brain barrier HDAC1/MAO-B inhibitor with IC50 values of 21.4 nM and 99.0 nM for HDAC1 and MAO-B, respectively. HDAC1/MAO-B-IN-1 has the potential for the research of Alzheimer’s disease[1]. |
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| Related Catalog | |
| Target |
HDAC1:21.4 nM (IC50) MAO-B:99.0 nM (IC50) |
| In Vitro | HDAC1/MAO-B-IN-1 (compound 1f) shows inhibitory activities with IC50s of 99.0 nM, 9923.0 nM, 21.4 nM for hMAO-B, hMAO-A, hHDAC1, respectively[1]. HDAC1/MAO-B-IN-1 (50 µM; 24 h) displays neuroprotective and inhibitory activity on ROS production in PC12 cells[1]. Cell Viability Assay[1] Cell Line: PC12 cells Concentration: 50 µM Incubation Time: 24 h Result: Displayed neuroprotective and inhibitory activity on ROS production. |
| In Vivo | HDAC1/MAO-B-IN-1 (20 mg/kg; i.g.) exhibits favorable BBB (blood–brain barrier) permeability[1]. HDAC1/MAO-B-IN-1 (15 mg/kg; i.p.) improves the learning and memory abilities of the ICR mice[1]. Animal Model: 6-8 weeks, ICR male mice[1] Dosage: 20 mg/kg Administration: I.g. Result: Exhibited favorable BBB (blood–brain barrier) permeability. Animal Model: 20-25 g, ICR female mice[1] Dosage: 15 mg/kg Administration: I.p.; 15 consecutive days Result: Improved the learning and memory abilities of the ICR mice. |
| References |
| Molecular Formula | C18H17ClN2O2 |
|---|---|
| Molecular Weight | 328.79 |