2834758-29-9

2834758-29-9 structure

Name: AChE/BuChE/MAO-B-IN-1
Chemical Name: AChE/BuChE/MAO-B-IN-1
CAS Number: 2834758-29-9
Molecular Formula: C₁₇H₂₃NO₃
Molecular Weight: 289.37
Catalog: Signaling Pathways Neuronal Signaling AChE
Create Date: 2022-12-02 20:48:50
Modify Date: 2025-08-25 18:09:58
AChE/BuChE/MAO-B-IN-1 (compound 19) is an inhibitor of human acetyl- (hAChE), butyrylcholinesterase (hBuChE) and monoamine oxidase-B (hMAO-B) with IC50s of 4.8 μM, 13.7 μM, and 1.11 μM, respectively. AChE/BuChE/MAO-B-IN-1 also exhibits high affinity to both the σ1 and σ2 receptors with Ki values of 42.8 nM (human σ1 receptor) and 191 nM (rat σ2 receptor), respectively. AChE/BuChE/MAO-B-IN-1 can be used for Alzheimer’s disease research[1].

Name	AChE/BuChE/MAO-B-IN-1

Description	AChE/BuChE/MAO-B-IN-1 (compound 19) is an inhibitor of human acetyl- (hAChE), butyrylcholinesterase (hBuChE) and monoamine oxidase-B (hMAO-B) with IC50s of 4.8 μM, 13.7 μM, and 1.11 μM, respectively. AChE/BuChE/MAO-B-IN-1 also exhibits high affinity to both the σ1 and σ2 receptors with Ki values of 42.8 nM (human σ1 receptor) and 191 nM (rat σ2 receptor), respectively. AChE/BuChE/MAO-B-IN-1 can be used for Alzheimer’s disease research[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	hAChE:4.8 μM (IC50) hBCHE:13.7 μM (IC50) hMAO-B:1.11 μM (IC50)
References	[1]. Tim Keuler, et al. The Chemotype of Chromanones as a Privileged Scaffold for Multineurotarget Anti-Alzheimer Agents. ACS Pharmacol. Transl. Sci. 2022, 12 Oct.

Molecular Formula	C₁₇H₂₃NO₃
Molecular Weight	289.37