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1801157-64-1

1801157-64-1 structure
1801157-64-1 structure
  • Name: Dual AChE-MAO B-IN-2
  • Chemical Name: Dual AChE-MAO B-IN-2
  • CAS Number: 1801157-64-1
  • Molecular Formula: C26H25NO4
  • Molecular Weight: 415.48
  • Create Date: 2022-05-20 08:16:49
  • Modify Date: 2024-01-11 15:52:14
  • Dual AChE-MAO B-IN-2 is a potent AChE and MAO B dual inhibitor with IC50s of 0.12 µM and 0.01 µM for b>AChE and MAO B, respectively. Dual AChE-MAO B-IN-2 has the potential for the research of Alzheimer’s disease[1].

Name Dual AChE-MAO B-IN-2
Description Dual AChE-MAO B-IN-2 is a potent AChE and MAO B dual inhibitor with IC50s of 0.12 µM and 0.01 µM for b>AChE and MAO B, respectively. Dual AChE-MAO B-IN-2 has the potential for the research of Alzheimer’s disease[1].
Related Catalog
Target

MAO-B:4.5 μM (Ki)

In Vitro Dual AChE-MAO B-IN-2 (compound 1) shows a +5.5 °C increase in the MAO B enzyme Tm value[1].
References

[1]. Ekström F, et al. Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures. ACS Med Chem Lett. 2022, 13(3):499-506.

Molecular Formula C26H25NO4
Molecular Weight 415.48
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