2503325-21-9
2503325-21-9 structure
- Name: Cbl-b-IN-2
- Chemical Name: Cbl-b-IN-2
- CAS Number: 2503325-21-9
- Molecular Formula: C29H30F5N5O2
- Molecular Weight: 575.57
- Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
- Create Date: 2022-09-13 00:45:06
- Modify Date: 2024-04-06 10:36:19
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Cbl-b-IN-2 (Example 8) is an orally bioavailable compound, can inhibit the E3 enzyme Casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) in the ubiquitin proteasome pathway. Cbl-b-IN-2 can be used to modulate the immune system and diseases amenable to immune system modulation. Cbl-b-IN-2 (Example 8) also may be administered to an individual with cancer, either alone or as part of a combination, with one or more of an immune checkpoint inhibitor, an anti-neoplastic agent, and radiation agent[1].
| Name | Cbl-b-IN-2 |
|---|
| Description | Cbl-b-IN-2 (Example 8) is an orally bioavailable compound, can inhibit the E3 enzyme Casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) in the ubiquitin proteasome pathway. Cbl-b-IN-2 can be used to modulate the immune system and diseases amenable to immune system modulation. Cbl-b-IN-2 (Example 8) also may be administered to an individual with cancer, either alone or as part of a combination, with one or more of an immune checkpoint inhibitor, an anti-neoplastic agent, and radiation agent[1]. |
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| Related Catalog | |
| In Vitro | Cbl-b-IN-2 (Example 8) is a Cbl-b inhibitor with IC50 values range of 5.1-100 nM and ﹤1 nM in high and low concentration of Cbl-b, respectively[1]. Cell Viability Assay[1] Cell Line: Immune cell Concentration: 0.125 nM, 0.15 nM Incubation Time: 1 h Result: Showed Cbl-b activity with an with IC50 values range of 5.1-100 nM and ﹤1 nM in high and low concentration of Cbl-b, respectively. |
| References |
| Molecular Formula | C29H30F5N5O2 |
|---|---|
| Molecular Weight | 575.57 |