892742-76-6
892742-76-6 structure
- Name: UT-B-IN-1
- Chemical Name: UT-B-IN-1
- CAS Number: 892742-76-6
- Molecular Formula: C20H17N5O2S3
- Molecular Weight: 455.58
- Catalog: Research Areas Metabolic Disease
- Create Date: 2023-05-06 12:37:58
- Modify Date: 2024-04-06 11:12:07
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UT-B-IN-1 (UTBINH-14) is a reversible, competitive and selective urea transporter-B (UT-B) inhibitor with IC50 values of 10 and 25 nM for human and mouse UT-B, respectively. UT-B-IN-1 shows low toxicity and high selectivity for UT-B over UT-A isoforms. UT-B-IN-1 increases urine output and reduces urine osmolality of mice. UT-B-IN-1 can be used for diuretic mechanism research[1].
| Name | UT-B-IN-1 |
|---|
| Description | UT-B-IN-1 (UTBINH-14) is a reversible, competitive and selective urea transporter-B (UT-B) inhibitor with IC50 values of 10 and 25 nM for human and mouse UT-B, respectively. UT-B-IN-1 shows low toxicity and high selectivity for UT-B over UT-A isoforms. UT-B-IN-1 increases urine output and reduces urine osmolality of mice. UT-B-IN-1 can be used for diuretic mechanism research[1]. |
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| Related Catalog | |
| Target |
IC50: 10 nM (human UT-B); 25 nM (mouse UT-B)[1] |
| In Vitro | UT-B-IN-1 (1-1000 nM) 抑制尿素预载红细胞的尿素外排，IC50 值为 26.7 nM[1]。 UT-B-IN-1 抑制 AQP1-null 红细胞的水运输[1]。 UT-B-IN-1 (0-10 μM；24 h) 对 MDCK 细胞无细胞毒性[1]。 Cell Cytotoxicity Assay[1] Cell Line: Madin-Darby canine kidney (MDCK) cell line Concentration: 0-10 μM Incubation Time: 24 hours Result: Exhibited no cytotoxic effect to MDCK cells. |
| In Vivo | UT-B-IN-1 (300 μg；腹腔注射，1 次) 在自由取水和进食的小鼠中，增加排尿量并降低尿液渗透性[1]。 Animal Model: Male mice (wild-type or UT-B knockout)[1] Dosage: 300 μg Administration: Intraperitoneal injection, 300 μg, once Result: Reduced urine osmolality and urea concentration in wild-type mice with V2-receptor agonist dDAVP injection. Increased urine volume and reduced urine osmolality and urea concentration in mice with free access to food and water but without dDAVP. |
| References |
| Molecular Formula | C20H17N5O2S3 |
|---|---|
| Molecular Weight | 455.58 |