HIV-1 inhibitor-45

Modify Date: 2024-04-03 20:29:17

HIV-1 inhibitor-45 structure	Common Name	HIV-1 inhibitor-45
	CAS Number	2677762-43-3	Molecular Weight	516.52
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₄N₄O₈S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HIV-1 inhibitor-45

HIV-1 inhibitor-45 (compound IA-6) is a potent HIV-1 RNase H inhibitor with an IC50 value of 0.067 μM. HIV-1 inhibitor-45 shows an antiviral activity[1].

Name	HIV-1 inhibitor-45

Description	HIV-1 inhibitor-45 (compound IA-6) is a potent HIV-1 RNase H inhibitor with an IC50 value of 0.067 μM. HIV-1 inhibitor-45 shows an antiviral activity[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	IC50: 0.067 μM (HIV-1 RNase H)[1]
In Vitro	HIV-1 inhibitor-45 (compound IA-6) (5 d) has antiviral activity and low toxicity with CC50 value of 24.7 μM in MT-4 cells[1]. HIV-1 inhibitor-45 (compound IA-6) (Caco-2 cells) contributes to the poormembrane permeability by polyphenolic skeleton[1].
References	[1]. Zhang L, et, al. Design, synthesis, and biological evaluation of novel double-winged galloyl derivatives as HIV-1 RNase H inhibitors. Eur J Med Chem. 2022 Jun 26;240:114563.

Molecular Formula	C₂₃H₂₄N₄O₈S
Molecular Weight	516.52