2771211-71-1

2771211-71-1 structure

Name: HIV-1 inhibitor-54
Chemical Name: HIV-1 inhibitor-54
CAS Number: 2771211-71-1
Molecular Formula: C₂₇H₃₀N₆O₄S
Molecular Weight: 534.63
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2023-03-30 17:13:31
Modify Date: 2024-04-09 12:20:39
HIV-1 inhibitor-54 is a potent HIV-1 inhibitor. HIV-1 inhibitor-54 has anti-HIV activity in MT-4 cells against WT HIV-1 (strain IIIB) with an EC50 value of 0.032 μM. HIV-1 inhibitor-54 can be used for the research of virus infection[1].

Name	HIV-1 inhibitor-54

Description	HIV-1 inhibitor-54 is a potent HIV-1 inhibitor. HIV-1 inhibitor-54 has anti-HIV activity in MT-4 cells against WT HIV-1 (strain IIIB) with an EC50 value of 0.032 μM. HIV-1 inhibitor-54 can be used for the research of virus infection[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HIV-1
In Vitro	HIV-1 inhibitor-54 (compound 4c) 对 HIV-1 突变体 E138K、K103 N、Y188L、Y181C、F227L+V106A 和 L100I 表现出较强的抗逆转录酶活性，其 EC50 值分别为 0.080 , 0.52, 0.67, 0.84, 2.7 和 3.3 μM[1]。 HIV-1 inhibitor-54 抑制野生型 HIV-1 逆转录的活性，IC50 值为 12 μM[1]。
References	[1]. Ming W, et al. Hybrids of delavirdine and piperdin-4-yl-aminopyrimidines (DPAPYs) as potent HIV-1 NNRTIs: Design, synthesis and biological activities. Eur J Med Chem. 2023 Feb 15;248:115114.

Molecular Formula	C₂₇H₃₀N₆O₄S
Molecular Weight	534.63