HIV-1 inhibitor-45

Names

[ Name ]:
HIV-1 inhibitor-45

Biological Activity

[Description]:

HIV-1 inhibitor-45 (compound IA-6) is a potent HIV-1 RNase H inhibitor with an IC50 value of 0.067 μM. HIV-1 inhibitor-45 shows an antiviral activity[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

[Target]

IC50: 0.067 μM (HIV-1 RNase H)[1]

[In Vitro]

HIV-1 inhibitor-45 (compound IA-6) (5 d) has antiviral activity and low toxicity with CC50 value of 24.7 μM in MT-4 cells[1]. HIV-1 inhibitor-45 (compound IA-6) (Caco-2 cells) contributes to the poormembrane permeability by polyphenolic skeleton[1].

[References]

[1]. Zhang L, et, al. Design, synthesis, and biological evaluation of novel double-winged galloyl derivatives as HIV-1 RNase H inhibitors. Eur J Med Chem. 2022 Jun 26;240:114563.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₄N₄O₈S

[ Molecular Weight ]:
516.52

Related Compounds

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